Results 61 to 70 of about 5,793 (229)
Conformation-directed macrocyclization reactions [PDF]
A review. The importance of conformational pre-organization in successful macrocyclization reactions was recognized ever since Eschenmoser's synthesis of vitamin B12 and Woodward's synthesis of erythromycin.
Blankenstein, Joerg, Zhu, Jieping
core +1 more source
Protein Conformational Stability Enhancement Through PEGylation and Macrocyclization [PDF]
, 2021 PEGylation can improve the pharmacokinetic properties of protein therapeutics via decreasing renal clearance and shielding the protein surface from proteases, antibody neutrailization, and aggregation.
Xiao, Qiang
core
MoleculesThe presented studies aimed to evaluate the peripheral coordinating properties of a novel porphyrinoid family representative preceded by its synthesis for potential sensing purposes.
Wojciech Szczolko +4 more
doaj +1 more source
Nature Communications, 2022 Macrocyclization is an important process in bioactive natural product synthesis. Here, the authors report on the study of a macrocyclic ring constructing enzyme in the biosynthesis of alchivemycin A and using gene deletion, biochemical assays and isotope
Hong Jie Zhu +11 more
doaj +1 more source
Thiol-Yne click chemistry of acetylene-enabled macrocyclization
Nature Communications, 2022 Thiol–yne coupling is a reliable method to link two molecular units, but has not been extensively explored for the construction of macrocycles. Here, the authors use gaseous acetylene, the simplest alkyne unit, to synthesize a variety of macrocycles ...
Shiwei Lü, Zipeng Wang, Shifa Zhu
doaj +1 more source
Angewandte Chemie International Edition, EarlyView.A strained macrocycle consisting solely of azulene subunits, named [6]cycloparaazulenylene ([6]CPA), is presented. The macrocycle exhibits a notably narrow HOMO–LUMO gap for a pristine azulene species, strain‐induced red‐shifted absorption, and an unusual tubular packing motif elucidated via single‐crystal XRD.
Clara Douglas +8 more
wiley +1 more source
Preparation of penta-azole containing cyclopeptides: challenges in macrocyclization [PDF]
, 2014 Herein is described the synthesis of several analogs of the natural product IB-01211 from concatenated azoles, via a biomimetic pathway based on cyclization-oxidation of serine containing peptides combined with the Hantzsch synthesis.
Álvarez Domingo, Mercedes +5 more
core +1 more source
6-Deoxyerythronolide B Synthase Thioesterase-Catalyzed Macrocyclization Is Highly Stereoselective [PDF]
, 2016 Macrocyclic polyketide natural products are an indispensable source of therapeutic agents. The final stage of their biosynthesis, macrocyclization, is catalyzed regio- and stereoselectively by a thioesterase.
Mark Horsman (2087140) +3 more
core +1 more source
Surface-Confined Macrocyclization via Dynamic Covalent Chemistry [PDF]
, 2020 Surface-confined synthesis is a promising approach to build complex molecular nanostructures including macrocycles. However, despite the recent advances in on-surface macrocyclization under ultrahigh vacuum, selective synthesis of monodisperse and ...
Lea Assies (8458734) +11 more
core +3 more sources
Multicomponent Macrocyclization Reactions (MCMRs) Employing Highly Reactive Acyl Ketene and Nitrile Oxide Intermediates [PDF]
, 2016 An efficient synthesis of spiro-fused macrolactams by a multicomponent macrocyclization reaction (MCMR) is reported. The use of highly reactive, transient intermediates in this MCMR permits short reaction times, even at high dilution.
Mark J. Kurth (1328874) +2 more
core +1 more source