Unprotected peptide macrocyclization and stapling via a fluorine-thiol displacement reaction
Nature Communications, 2022 Strategies capable of stapling unprotected peptides in a straightforward, chemoselective, and clean manner, as well as promoting cellular uptake are of great interest.
Md Shafiqul Islam +13 more
doaj +1 more source
Stepwise Synthesis of Tetrabenzotriazaporphyrins (TBTAPs) and Their Open 2- and 3-Ring Fragments. [PDF]
ChemistryUnexpected reaction pathways to porphyrin‐phthalocyanine hybrids are uncovered by the synthesis of “half‐macrocycle” fragments and subsequent macrocyclization. Rather than the expected 2:2 “ABBA” product, the 3:1 “ABBB” hybrid is isolated as the only macrocyclic product.
Gretton J +10 more
europepmc +2 more sources
Macrocyclization of Fischer Carbene Complexes as an Approach to Cyclophanes
, 2016 Macrocyclization of Fischer Carbene Complexes as an Approach to ...
William D. Wulff (1338240) +1 more
core +1 more source
Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation
Communications Chemistry, 2023 Head-to-tail macrocyclization of proteins and peptides can increase their structural stability, however, potential polymerization can lead to reduced yields.
Xinying Jia +10 more
doaj +1 more source
Chirality-Matched Catalyst-Controlled Macrocyclization Reactions [PDF]
, 2021 Macrocycles, formally defined as compounds that contain a ring with 12 or more atoms, continueto attract great interest due to their important applications in physical, pharmacological andenvironmental sciences.
Scott, Miller +2 more
core +2 more sources
Light-Mediated Desulfurization of Peptides in Multi-Well Format for Combinatorial Library Synthesis
MoleculesNative chemical ligation (NCL) combined with post-ligation desulfurization is a powerful strategy for the chemical joining of unprotected peptide segments to form larger polypeptides or to synthesize head-to-tail cyclized peptides.
Esther Arentoft Jacobsen +8 more
doaj +1 more source
Total Synthesis and Pharmacological Investigation of Cordyheptapeptide A
Molecules, 2017 The present investigation reports the synthesis of a phenylalanine-rich N-methylated cyclopeptide, cordyheptapeptide A (8), previously isolated from the insect pathogenic fungus Cordyceps sp.
Suresh Kumar +5 more
doaj +1 more source
Small Natural Cyclic Peptides from DBAASP Database
PharmaceuticalsAntimicrobial peptides (AMPs) are promising tools for combating microbial resistance. However, their therapeutic potential is hindered by two intrinsic drawbacks—low target affinity and poor in vivo stability.
Evgenia Alimbarashvili +3 more
doaj +1 more source
6-Deoxyerythronolide B Synthase Thioesterase-Catalyzed Macrocyclization Is Highly Stereoselective
, 2016 Macrocyclic polyketide natural products are an indispensable source of therapeutic agents. The final stage of their biosynthesis, macrocyclization, is catalyzed regio- and stereoselectively by a thioesterase.
Mark Horsman (2087140) +3 more
core +1 more source
Angewandte Chemie, EarlyView.Catalytic, intramolecular N‐heterocycle arylation by nucleophilic aromatic substitution (SNAr) is now available for synthesis of highly strained macrocycles and medium‐sized heterobiaryl atropisomeric rings, including atropopeptides. Key to the approach is the ability to generate a strong base catalytically, taking advantage of base‐embedding ...
Alireza Abbasi Kejani +7 more
wiley +1 more source