Results 31 to 40 of about 25,345 (208)

Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists

Beilstein Journal of Organic Chemistry, 2019
Macrocycles were designed to antagonize the protein–protein interaction p53-MDM2 based on the three-finger pharmacophore F19W23L25. The synthesis was accomplished by a rapid, one-pot synthesis of indole-based macrocycles based on Ugi macrocyclization ...
Constantinos G. Neochoritis, Maryam Kazemi Miraki, Eman M. M. Abdelraheem, Ewa Surmiak, Tryfon Zarganes-Tzitzikas, Beata Łabuzek, Tad A. Holak, Alexander Dömling   +7 more
doaj   +1 more source

Thiol-Yne click chemistry of acetylene-enabled macrocyclization

Nature Communications, 2022
Thiol–yne coupling is a reliable method to link two molecular units, but has not been extensively explored for the construction of macrocycles. Here, the authors use gaseous acetylene, the simplest alkyne unit, to synthesize a variety of macrocycles ...
Shiwei Lü, Zipeng Wang, Shifa Zhu
doaj   +1 more source

Synthesis of new p-tert-butylcalix[4]arene-based polyammonium triazolyl amphiphiles and their binding with nucleoside phosphates

Beilstein Journal of Organic Chemistry, 2018
The synthesis of new calix[4]arenes adopting a cone stereoisomeric form bearing two or four azide fragments on the upper rim and water-soluble triazolyl amphiphilic receptors with two or four polyammonium headgroups via copper-catalyzed azide–alkyne ...
Vladimir A. Burilov, Guzaliya A. Fatikhova, Mariya N. Dokuchaeva, Ramil I. Nugmanov, Diana A. Mironova, Pavel V. Dorovatovskii, Victor N. Khrustalev, Svetlana E. Solovieva, Igor S. Antipin   +8 more
doaj   +1 more source

Inner-bond-cleavage approach to figure-eight macrocycles from planar aromatic hydrocarbons [PDF]

Contemporary synthetic strategies in organic chemistry rely heavily on the stepwise formation of bonds between fragments of the target compound (‘bottom-up’ approach). Figure-eight aromatic macrocycles represent a considerable challenge for the bottom-up
Reiji , Yoshina, Guanting , Liu, Junichiro , Hirano, Eiji , Yashima, Akinori , Saeki, Emiko , Nishimoto, Jinseok , Kim, Norihito, Fukui, Juwon , Oh, Tomoyuki, Ikai, Shunsuke , Minabe, Dongho , Kim, Takuma , Yasuda, Hiroshi , Shinokubo, Takuya , Omine, Yuki , Sakamoto, Fumitaka, Ishiwari, Keita , Tajima, Muhammet , Uyanik, Kazuaki , Ishihara   +19 more
core   +2 more sources

Shape switchable azo macrocycles [PDF]

, 2011
The present thesis is organized in three main chapters. The first section discusses a research project for the integration of azobenzene motives as a functional unit in macrocyclic molecular structures.
Müri, Marcel
core   +1 more source

Multicomponent Syntheses of Macrocycles

, 2010
How to access efficiently the macrocyclic structure remained to be a challenging synthetic topic. Although many elegant approaches/reactions have been developed, construction of diverse collection of macrocycles is still elusive.
Jieping Zhu, Luc Neuville, Neuville, L., Burghin, Carine, Fayol, Audie, Aude Fayol, Masson, G., Géraldine Masson, Zhu, Jieping, Zhu, J., Carine Bughin, Fayol, A., Masson, Géraldine, Neuville, Luc, Bughin, C.   +14 more
core   +1 more source

Olefinic-Lactone Cyclizations to Macrocycles

, 2016
Olefinic-lactone cyclization reactions that result in the generation of macrocycles are ...
Jon D. Rainier (1688194), John C. Rohanna (2398009)   +1 more
core   +2 more sources

Low‐entropy‐penalty synthesis of giant macrocycles for good self‐assembly and emission enhancement

Aggregate
Macrocycles are key tools for molecular recognition and self‐assembly. However, traditionally prevalent macrocyclic compounds exhibit specific cavities with diameters usually less than 1 nm, limiting their range of applications in supramolecular ...
Xiao‐Na Sun, Ao Liu, Kaidi Xu, Zhe Zheng, Kai Xu, Ming Dong, Bo Ding, Jian Li, Zhi‐Yuan Zhang, Chunju Li   +9 more
doaj   +1 more source

Unraveling the therapeutic landscape of approved non-peptide macrocycles

Acta Pharmaceutica Sinica B
Non-peptide macrocyclic drugs possess unique structural advantages that allow them to target various biomolecules of interest and thus show therapeutic potential against various diseases such as cancer, infectious diseases, etc.
Zhonghua Li, Zhenqiang Zhang, Bin Yu
doaj   +1 more source

The Abiotic Formation of Pyrrole under Volcanic, Hydrothermal Conditions—An Initial Step towards Life’s First Breath?

Life, 2021
Porphyrins, corrins, and tetrapyrroles constitute macrocycles in essential biomolecules such as heme, chlorophyll, cobalamin, and cofactor F430.
Christian Seitz, Wolfgang Eisenreich, Claudia Huber   +2 more
doaj   +1 more source