Results 11 to 20 of about 25,345 (208)
Synlett, 2018 Artificial macrocycles recently became popular as a novel research field in drug discovery. As opposed to their natural twins, artificial macrocycles promise to have better control on synthesizability and control over their physicochemical properties resulting in druglike properties. Very few synthetic methods allow for the convergent, fast but diverse
Abdelraheem +3 more
openaire +4 more sources
Design, synthesis and applications of responsive macrocycles [PDF]
Communications Chemistry, 2020 Macrocycles have been widely studied for their structure-specific and highly selective recognition properties. Here the authors review the design, synthesis and applications of photo-, pH- and redox-responsive macrocycles.
Jingjing Yu, Dawei Qi, Jianwei Li
doaj +2 more sources
Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles [PDF]
Molecules, 2013 Macrocyclic scaffolds are commonly found in bioactive natural products and pharmaceutical molecules. So far, a large number of macrocyclic natural products have been isolated and synthesized.
Xufen Yu, Dianqing Sun
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Synthesis of Bioactive Macrocycles Involving Ring-Closing Metathesis Strategy
SynOpen, 2023 This review reports the synthesis of various bioactive macrocycles, involving ring-closing metathesis as a key step, developed since ca. 2000. These macrocycles exhibited biological activities such as antiviral, antifungal, antibacterial, and anticancer ...
Nasrin Jahan, Inul Ansary
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A membrane permeability database for nonpeptidic macrocycles
Scientific DataThe process of developing new drugs is arduous and costly, particularly for targets classified as “difficult-to-drug.” Macrocycles show a particular ability to modulate difficult-to-drug targets, including protein-protein interactions, while still ...
Qiushi Feng +3 more
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Macrocycles of Higher ortho-Phenylenes: Assembly and Folding [PDF]
, 2019 Higher-order structure in abiotic foldamer systems represents an important but largely unrealized goal. As one approach to this challenge, covalent assembly can be used to assemble macrocycles with foldamer subunits in well-defined spatial relationships.
Viraj Kirinda (6668226) +5 more
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Pathway Complexity in the Stacking of Imine-linked Macrocycles Related to Two-Dimensional Covalent Organic Frameworks [PDF]
, 2019 This work reports on the assembly of imine-linked macrocycles that serve as models of two-dimensional covalent organic frameworks (2D COFs). Interlayer interactions play an important role in the formation of 2D COFs, yet the effect of monomer structure ...
Chao, Sun +10 more
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Assembly and Disassembly of Supramolecular Hypervalent Iodine Macrocycles via Anion Coordination [PDF]
, 2023 This study explores the dynamic self-assembly of hypervalent iodine-based macrocycles (HIMs) driven by secondary bonding interactions. The reversible disassembly and reassembly of HIMs are facilitated through anion binding via addition of ...
Gajanan, Kulkarni +6 more
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Indole-Based Macrocyclization by Metal-Catalyzed Approaches
Organics, 2023 This review is dedicated to the different varieties of macrocycles synthesis bearing indole units in their architecture by metal-catalyzed strategies.
Subba Rao Cheekatla +4 more
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Synthesis and Screening of A DNA-Encoded Library of Non-Peptidic Macrocycles [PDF]
, 2020 There is considerable interest in the development of libraries of non-peptidic macrocycles as a source of ligands for difficult targets. We report here the solid-phase synthesis of a DNA-encoded library of several hundred thousand thioether-linked ...
Animesh, Roy +3 more
core +2 more sources