Results 11 to 20 of about 9,528 (245)
Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles [PDF]
Molecules, 2013 Macrocyclic scaffolds are commonly found in bioactive natural products and pharmaceutical molecules. So far, a large number of macrocyclic natural products have been isolated and synthesized.
Xufen Yu, Dianqing Sun
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Synlett, 2018 Artificial macrocycles recently became popular as a novel research field in drug discovery. As opposed to their natural twins, artificial macrocycles promise to have better control on synthesizability and control over their physicochemical properties resulting in druglike properties. Very few synthetic methods allow for the convergent, fast but diverse
Abdelraheem +3 more
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Symmetric Macrocycles by a Prins Dimerization and Macrocyclization Strategy [PDF]
Organic Letters, 2009 A tandem dimerization/macrocyclization reaction utilizing the Prins cyclization has been developed. This reaction develops molecular complexity through the formation of highly substituted dimeric tetrahydropyran macrocycles. Mild conditions utilizing rhenium(VII) catalysts were explored for aromatic substrates, while harsher Lewis acidic conditions ...
Michael R, Gesinski +2 more
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Nanomaterials, 2023 Macrocycles have attracted significant attention from academia due to their various applications in organic field-effect transistors, organic light-emitting diodes, organic photovoltaics, and dye-sensitized solar cells.
Chunxiao Zhong +9 more
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Size-control in the synthesis of oxo-bridged phosphazane macrocycles via a modular addition approach
Communications Chemistry, 2021 Cyclodiphosphazane macrocycles have demonstrated promising host-guest chemistry, but synthetic routes to highorder versions are lacking. Here the authors synthesise high-order oxygen-bridged phosphazane macrocycles via a modular cyclisation strategy.
Xiaoyan Shi +5 more
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Parallel Synthesis of Peptide-Like Macrocycles Containing Imidazole-4,5-dicarboxylic Acid
Molecules, 2012 We prepared a series of peptide-like 14-membered macrocycles containing an imidazole-4,5-dicarboxylic acid scaffold by using known coupling reagents and protecting group strategies.
Paul W. Baures +2 more
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Insight into functionalized-macrocycles-guided supramolecular photocatalysis
Beilstein Journal of Organic Chemistry, 2021 Due to the unique characteristics of macrocycles (e.g., the ease of modification, hydrophobic cavities, and specific guest recognition), they can provide a suitable environment to realize photocatalysis via noncovalent interactions with different ...
Minzan Zuo +4 more
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Communications Chemistry, 2023 Aromaticity can be assigned by Hückel’s rule, which predicts that planar rings with delocalized (4n + 2) π-electrons are aromatic, whereas those with 4n π-electrons are antiaromatic.
Yuval Rahav +4 more
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Aza-Oxa-Triazole Based Macrocycles with Tunable Properties: Design, Synthesis, and Bioactivity
Molecules, 2022 A modular platform for the synthesis of tunable aza-oxa-based macrocycles was established. Modulations in the backbone and the side-chain functional groups have been rendered to achieve the tunable property.
Subba Rao Cheekatla +4 more
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Design, synthesis and applications of responsive macrocycles
Communications Chemistry, 2020 Macrocycles have been widely studied for their structure-specific and highly selective recognition properties. Here the authors review the design, synthesis and applications of photo-, pH- and redox-responsive macrocycles.
Jingjing Yu, Dawei Qi, Jianwei Li
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