Results 21 to 30 of about 9,528 (245)
Indole-Based Macrocyclization by Metal-Catalyzed Approaches
Organics, 2023 This review is dedicated to the different varieties of macrocycles synthesis bearing indole units in their architecture by metal-catalyzed strategies.
Subba Rao Cheekatla +4 more
doaj +1 more source
Oxidative Carbocation Formation in Macrocycles: Synthesis of the Neopeltolide Macrocycle [PDF]
Angewandte Chemie, 2009 AbstractMakrocyclische Oxocarbeniumionen wurden aus Makrolactonen mit Benzyl‐ oder Allyletherfunktionen durch oxidative C‐H‐Bindungsaktivierung in Gegenwart von 2,3‐Dichlor‐4,5‐dicyanchinon (DDQ) erhalten. Die Nützlichkeit dieser effizienten Reaktion für die Synthese komplexer Moleküle wurde anhand ihrer Verwendung zum Aufbau des Tetrahydropyronrings ...
Wangyang, Tu, Paul E, Floreancig
openaire +2 more sources
Nature Communications, 2022 Macrocycles have potential as therapeutics, but their libraries are currently not large enough for high-throughput screening. Here, the authors show a combinatorial approach to generate a library of almost 20’000 macrocycles by conjugating carboxylic ...
Sevan Habeshian +12 more
doaj +1 more source
Tetraruthenium Metallamacrocycles with Potentially Coordinating Appended Functionalities
Inorganics, 2018 We present four new tetraruthenium macrocycles built from two 1,4-divinylphenylene diruthenium and two isophthalic acid building blocks with peripheral, potentially mono- or tridentate donor functions attached to the isophthalic linkers.
Patrick Anders +3 more
doaj +1 more source
Nanoarchitectonics of Exfoliated Flexible Nanosheet Based on Laterally Stacked Macrocycles
Advanced Materials Interfaces, 2023 2D nanostructures including monolayers and few layers exhibit unique properties originating from the anisotropic ultrathin nature. Conventional organic 2D nanostructures, such as covalent organic frameworks, are comprised of the planar π‐conjugated ...
Nano Shioda +5 more
doaj +1 more source
A Convergent Synthesis of the Macrocyclic Core of Cytotrienins: Application of RCM for Macrocyclization [PDF]
Organic Letters, 2004 AbstractFor Abstract see ChemInform Abstract in Full Text.
Evano, Gwilherm, Schaus, JV, Panek, JS
openaire +3 more sources
Antimicrobial Activity of Calixarenes and Related Macrocycles
Molecules, 2020 Calixarenes and related macrocycles have been shown to have antimicrobial effects since the 1950s. This review highlights the antimicrobial properties of almost 200 calixarenes, resorcinarenes, and pillararenes acting as prodrugs, drug delivery agents ...
Dmitriy N. Shurpik +3 more
doaj +1 more source
Synthesis of Highly Functionalized Macrocycles by the Peripheral Functionalization of Macrocyclic Diimines [PDF]
The Journal of Organic Chemistry, 2006 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Miguel A, Sierra +4 more
openaire +2 more sources
Macrocyclic Inhibitors of Hsp90 [PDF]
Current Topics in Medicinal Chemistry, 2010 Heat shock proteins (HSP) are a family of highly conserved proteins, whose expression increases in response to stresses that may threaten cell survival. Over the past decade, heat shock protein 90 (Hsp90) has emerged as a potential therapeutic target for cancer as it plays a vital role in normal cell maturation and acts as a molecular chaperone for ...
Johnson, V +4 more
openaire +3 more sources
Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists
Beilstein Journal of Organic Chemistry, 2019 Macrocycles were designed to antagonize the protein–protein interaction p53-MDM2 based on the three-finger pharmacophore F19W23L25. The synthesis was accomplished by a rapid, one-pot synthesis of indole-based macrocycles based on Ugi macrocyclization ...
Constantinos G. Neochoritis +7 more
doaj +1 more source