Results 61 to 70 of about 442 (127)

Heterochiral coupling in non-ribosomal peptide macrolactamization

Heterochiral coupling in non-ribosomal peptide macrolactamization
Heterochiral coupling is favoured in abiotic peptide bond formation, whereas biotic peptide bond formation is dominated by homochiral coupling. Here, we report that heterochiral coupling is a rather general paradigm in the head-to-tail macrolactamization of non-ribosomal peptide biosynthesis. The canonical cis-acting offloading cyclases, such as type I
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Macrocyclizing-thioesterases in bacterial non-ribosomal peptide biosynthesis. [PDF]

J Nat Med
Matsuda K.
europepmc   +1 more source

Scalable Total Synthesis, IP3R Inhibitory Activity of Desmethylxestospongin B, and Effect on Mitochondrial Function and Cancer Cell Survival. [PDF]

Angew Chem Int Ed Engl, 2021
Podunavac M, Mailyan AK, Jackson JJ, Lovy A, Farias P, Huerta H, Molgó J, Cardenas C, Zakarian A.   +8 more
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Isolation, total synthesis and structure determination of antifungal macrocyclic depsipeptide, tetraselide. [PDF]

Chem Sci
Nakahara H, Sennari G, Azami H, Tsutsumi H, Watanabe Y, Noguchi Y, Inahashi Y, Iwatsuki M, Hirose T, Sunazuka T.   +9 more
europepmc   +1 more source

Multistep Cascade Catalyzed by a Single-Chiral Lewis Acid: Efficient Asymmetric Synthesis of Macrocyclic Chiral Dilactones and Dilactams. [PDF]

JACS Au
Wang BL, Yu JQ, Zhang Q, Wang XW.
europepmc   +1 more source

Rapid Peptide Cyclization Inspired by the Modular Logic of Nonribosomal Peptide Synthetases. [PDF]

J Am Chem Soc
Ding Y, Lambden E, Peate J, Picken LJ, Rees TW, Perez-Ortiz G, Newgas SA, Spicer LAR, Hicks T, Hess J, Ulmschneider MB, Müller MM, Barry SM.   +12 more
europepmc   +1 more source

Stereoselective Synthesis and Antiproliferative Activity of Nemamide Analogs. [PDF]

J Nat Prod
Yu R, Gonzalez MS, Rakshit S, Li Y, Dar AR, Li X, Butcher RA.   +6 more
europepmc   +1 more source

Chemoenzymatic synthesis of macrocyclic peptides and polyketides via thioesterase-catalyzed macrocyclization. [PDF]

Beilstein J Org Chem
Qiao S, Cheng Z, Li F.
europepmc   +1 more source

Non-ribosomal peptide cyclase-directed chemoenzymatic synthesis of lariat lipopeptides. [PDF]

Nat Chem
Kobayashi M, Matsuda K, Yamada Y, Ichihara R, Onozawa N, Fukano H, Hoshino Y, Hirabayashi A, Suzuki M, Katsuyama A, Ichikawa S, Wakimoto T.   +11 more
europepmc   +1 more source

Synergy of Prediction Rule and Total Synthesis in Solving the Stereochemical Puzzle of Valactamides. [PDF]

Precis Chem
Zhang T, Feng J, Oikawa H, Guo Y, Ye T.
europepmc   +1 more source