Results 111 to 120 of about 544,173 (300)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Risk Assessment of Bioaccumulation Substances. Part II: Description of a Model Framework [PDF]
, 2009 This report provides a proposal for a framework for risk assessment of bioaccumulative substances, either from produced water discharges or present as background contamination.
Vries, P., de, Karman, C.C., Tamis, J.E.
core
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
AgronomyLong-term cultivation practices, in which mineral fertilizers are the only amendments made to crop-supporting soils, are giving rise to the degradation of soil structures in the world’s most fertile soils.
Michael H. B. Hayes, Maria Roulia
doaj +1 more source
Macromolecular excipients exert biological effects via their microbial fermentation absorbable products. [PDF]
, 2016 Fermentation of these macromolecular food or pharmaceutical excipient ingredients by the gut microbiota leads to the formation of short chain fatty acids (SCFA) which can be absorbed from the gut into the general circulation.
Shireesh Apte
core
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Uncharacterized and uncharacterizable attributes of macromolecular excipients [PDF]
Macromolecular excipients are unique in that each (macro)molecule or polymer chain can chemically differ significantly from another. However, these differences may not be detected across different lots or different samples because the analytical methods ...
Shireesh Apte
core +1 more source
A Whole City Response to the Use of Novel Psychoactive Substances (NPS) by Young People in Newcastle-upon-Tyne [PDF]
, 2015 In recent years, Novel Psychoactive Substances (NPS) (otherwise known as ‘legal highs’) have posed an increasingly significant problem for practitioners and policy makers due to their widespread availability, largely unknown chemical composition and ...
Irving, Adele +2 more
core
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source