Results 121 to 130 of about 32,992 (301)
Dynamic structure of humic substances: Rare earth elements as a fingerprint
, 2010 International audienceWhereas humic substances are known to play a key role in controlling metal speciation and trace element mobility within soils and waters, the understanding of their structure is still unclear and remains a matter of debate.
Davranche, Mélanie +2 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Simultaneous Presence of Diverse Molecular Patterns in Humic Substances in Solution
, 2016 The chemical and structural nature of humic substances (HS) is the object of an intense debate in the literature involving two main theoretical positions: the classical view defending the macromolecular pattern, and the new, more recent, view proposing ...
Marta Fuentes (2477494) +3 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2008 The vibrating membrane bioreactor (VMBR) system facilitates the possibility of conducting a separation of macromolecules (BSA) from larger biological components (yeast cells) with a relatively high and stable macromolecular transmission at sub-critical ...
Beier, Søren +3 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The mechanism of cloud loss phenomena in orange juice
, 1974 The importance of many factors for the cloud stability of orange juice was investigated. By the determination of methanol, cloud loss of orange juice could be ascribed directly to the action of pectin esterase.
Krop, J.J.P.
core
, 2012 Pyrolysis has been used for the last ten years to study the chemical nature of humic substances. However, obtaining data is hampered by analytical limitations.
Ortega Calvo, J. J. +2 more
core +1 more source
AgronomyLong-term cultivation practices, in which mineral fertilizers are the only amendments made to crop-supporting soils, are giving rise to the degradation of soil structures in the world’s most fertile soils.
Michael H. B. Hayes, Maria Roulia
doaj +1 more source