Results 141 to 150 of about 32,992 (301)

Metabolites of xenobiotica and mineral oil constituents linked to macromolecular organic matter in polluted environments

, 1994
The type of association between pollutants and humic substances of soils, sediments and river waters has been investigated. Metabolites, which can arise from the microbiological degradation of polyaromatic hydrocarbons (PAH) and polychlorinated biphenyls
Richnow, H. H., Hefter, Jens, Michaelis, W., Seifert, R., Kästner, M., Mahro, B.   +5 more
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Macromolecular Therapeutic Systems

Hydrophilic polymers are of special interest for application in medicine due to their biocompatibility, solubility and ability to absorb water. One of the most ancient and at the same time the most popular polymer is poly (vinyl alcohol) (PVA).
Savenkova, Ludmila, Dzenis, Mārcis, Tupureina, Velta, Loginova, Nataļja, Dzene, Anda, Staško (Greidāne), Jolanta   +5 more
core  

Investigation on the Therapeutic Mechanism of Danbie Capsules for Endometriosis: A Network Pharmacology Approach

International Journal of General Medicine
Lina Zhang,1– 3,* Ruibin Wu,2,3,* Tenghui Ma,2,3 Wenwen Fu,2,3 Jiamin Chen,2,3 Lingling Li,2,3 Qing He2,3 1The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510080, People’s Republic of China; 2Department of
Zhang L, Wu R, Ma T, Fu W, Chen J, Li L, He Q   +6 more
doaj  

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Research progress of central nervous system lymphatic circulation and related diseases

Chinese Journal of Contemporary Neurology and Neurosurgery, 2015
In this paper, we have reviewed the central nervous system (CNS) lymphatic circulation and related diseases. The lymphatic system is an important component of circulatory system.
Tian-ming LÜ, Xiao-yu HUANG, Cui-li SHI
doaj  

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Chaotropic and hydrophobic stress mechanisms of antifungal substances

, 2014
Growth and metabolism of fungi can be curtailed by chaotropic solutes and hydrophobic substances, both of which can weaken or inhibit non-covalent interactions within and between macromolecular systems.
Hallsworth, J. E., Patil, S. V., Iwaguchi , S, Saha, D, Timson, D. J., Chakraborty, D, Cray, J. A., Bhaganna, P., Singhal, R. S.   +8 more
core  

Fermentation process of tobacco leaves drives the specific changes of microbial community

BMC Microbiology
Background The changes of microbial community on tobacco leaves are affected by several factors during fermentation. However, the relative contribution of different factors in determining microbial community is not clear.
Jiemeng Tao, Shanyi Chen, Zhenkun Jiang, Chen Wang, Enren Zhang, Hui Liang, Yalong Xu, Peijian Cao, Ning Ding, Mingqian Zhang, Wei He, Qiansi Chen   +11 more
doaj   +1 more source