Results 181 to 190 of about 934,203 (313)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The macromolecular constitution of the CR chondrites [PDF]

, 2001
Gilmour, I., Pearson, V. K, Sephton, M. A.   +2 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

From Thiopheneboroles to Boron-containing Conjugated Macromolecules via Electropolymerization

, 2013
Shotaro Hayashi, Toshio Koizumi
openalex   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Prediction of Protein-Ligand Binding Affinities Using Atomic Surface Site Interaction Points. [PDF]

J Chem Inf Model
Zator KJ, Storer MC, Hunter CA.
europepmc   +1 more source

Extracellular vesicles as bioactive macromolecules vectors : model of the ABCC7 transporter (CFTR) and application to the biotherapy of cystic fibrosis

, 2015
Cyrielle Vituret
openalex   +1 more source

The Configuration of the Perivascular System Transporting Macromolecules in the CNS

, 2019
Beata Durcanova, Janine Appleton, N. Gurijala, Vasily Belov, Pilar Giffenig, Elisabeth Ludlage Moeller, Matthew Hogan, Fredella Lee, Mikhail Papisov   +8 more
openalex   +1 more source

Preparation of Porous Macromolecule Oxazine Poly-Ionic Liquid Solid Acid Catalyst and its Application in Esterification Reaction

, 2022
Yajuan Wang, Juan Zhang, Wenqiang Liu, Qingwen Shan   +3 more
openalex   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source