Results 281 to 290 of about 1,133,037 (342)

A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment

Advanced Healthcare Materials, EarlyView.
A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim, Tianxin Cao, Zhengpeng Wan, Jaesang Kim, Zhuxuan Li, Legairre A. Radden II, Rakesh Santhanam, Eunkyung Clare Ko, Tatsuya Osaki, Sarah Spitz, Hyunmin Moon, Maria Proestaki, Seokbeom Roh, Gyudo Lee, Jessie S. Jeon, Curtis R. Warren, Roger D. Kamm   +16 more
wiley   +1 more source

Thin-cap fibroatheroma association with local inflammatory activity in coronary disease: an optical-coherence tomography study. [PDF]

Einstein (Sao Paulo)
Garzon S, Pinheiro LFM, Bezerra FM, Prado GFA, Mariani J, Bandeira WC, Almeida BO, Lemos Neto PA.   +7 more
europepmc   +1 more source

Visible Light Induced DLP‐Printed Oxygen‐Releasing TPMS Scaffolds Mitigate Early Hypoxia in Bone Defects

Advanced Healthcare Materials, EarlyView.
Visible light‐induced digital light processing 3D printed Primitive‐triply periodic minimal surface hydrogels embed CaO2–Si core–shell nanoparticles to deliver short‐term oxygen during the avascular window. The scaffolds maintain cytocompatibility, elevate osteopontin in vitro, and enhance calvarial defect repair in vivo without toxicity.
Anastasia B. Timoshenko, Ali Ghasemkhani, Chanul Kim, Domenic J. Cordova, Maria Astudillo Potes, Valeria Aceves, Indranath Mitra, Justin E. Bird, Ryan S. Gray, Stephanie K. Seidlits, Benjamin D. Elder, Maryam Tilton   +11 more
wiley   +1 more source

The cellular triangle in bronchiectasis: the interplay network and regulatory mechanisms of neutrophils, macrophages, and epithelial cells. [PDF]

Eur J Med Res
Liang JF, Bai XL, Fan JX, Zhang JK, Liu XS.   +4 more
europepmc   +1 more source

Shedding Light on the Cellular Uptake Mechanisms of Bioactive Glass Nanoparticles as Controlled Intracellular Delivery Platforms: A Review of the Recent Literature

Advanced Healthcare Materials, EarlyView.
This review summarizes the main uptake pathways of bioactive glass nanoparticles (BGNs) and their intracellular localization, highlighting that BGNs are mainly internalized and entrapped within endosomes/lysosomes. Strategies for controlled intracellular ion release, with implications for targeted modulation of cell behavior, are discussed. The need to
Andrada‐Ioana Damian‐Buda, Aldo R. Boccaccini   +1 more
wiley   +1 more source

Chronic compression induces transcriptional, metabolic, and functional state changes in macrophages that recapitulate tumor-associated phenotypes. [PDF]

Front Immunol
Burchett Darantiere A, Chen H, Najera J, Howard S, Datta M.   +4 more
europepmc   +1 more source

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

Cell-specific roles of autophagy in liver fibrosis: implications for targeted pharmacotherapy. [PDF]

Ann Med
Liu C, Yang H, Liu Y, An M, Weng Z, Li L.   +5 more
europepmc   +1 more source

A Robust Heparin‐Mimicking Polyglycerol‐Based Coating for Blood‐Contacting Devices with Long‐Term Hemocompatibility and Preliminary Anti‐Inflammatory Properties

Advanced Healthcare Materials, EarlyView.
A robust heparin‐mimicking coating based on sulfated polyglycerol is constructed via layer‐by‐layer assembly on bloodcontacting surfaces. The coating exhibits long‐term anticoagulant and anti‐inflammatory properties by resisting protein adsorption, preventing platelet activation, and suppressing immune responses, offering a promising strategy for ...
Kunpeng Liu, Philip Nickl, Jun Feng, Rainer Haag   +3 more
wiley   +1 more source

Metabolic Reprogramming Intermediates of Glucose Regulate Macrophage Polarization: An Important Direction for Ameliorating Pulmonary Vascular Remodeling. [PDF]

J Inflamm Res
Wang J, Yuan R, Zhang S, Xu Z, Song L.
europepmc   +1 more source