Results 291 to 300 of about 1,143,350 (343)

Biomimetic Fibrinogen Nanofiber Scaffolds for Vascular Hematopoietic Stem Cell Niche Engineering

Advanced Healthcare Materials, EarlyView.
This study presents an advanced in vitro model of the vascular hematopoietic stem cell niche using self‐assembled fibrinogen nanofibers, mimicking the basement membrane in bone marrow (BM) sinusoids. The model supports the coculture of microvascular endothelial cells, stromal cells, and hematopoietic stem and progenitor cells, providing insights into ...
Sophia Lena Meermeyer, Arundhati Joshi, Constantin von Kaisenberg, Dorothea Brüggemann, Cornelia Lee‐Thedieck   +4 more
wiley   +1 more source

Recent advances and challenges in hydrogel-based delivery of immunomodulatory strategies for diabetic wound healing. [PDF]

Theranostics
Du L, Lin C, Hu H, Zhao Y, Liao J, Al-Smadi F, Mi B, Hu Y, Liu G.   +8 more
europepmc   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Intracellular Calcium as a Regulator of Polarization and Target Reprogramming of Macrophages. [PDF]

Int J Mol Sci
Pogonyalova MY, Popov DY, Vinokurov AY.
europepmc   +1 more source

A Functional Polymorphism of the Granulocyte Macrophage Colony Stimulating Factor is not Associated with the Outcome of HTLV-I Infection

, 2010
Abbas Shirdel, Houshang Rafatpanah, Hassan Rahimi, Seyed Abdolrahim Rezaee, Mahmoud Reza, Akram Beyk, Ian V. Hutchinson   +6 more
openalex   +1 more source

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

Advanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu, Ruiqi Wu, Hai Jiang, Lian Chen, Yingying Tian, Shuai Zeng, Tongmin Liu, Cheng Zhao, Huifeng Shi, Xiaolong Liang, Yangyu Zhao   +10 more
wiley   +1 more source

Progress in Research on Macrophage Polarization Mechanisms and Targeted Therapies in <i>Staphylococcus aureus</i> Infections. [PDF]

Infect Drug Resist
Yan W, Li X, Xu S, Pan H, Wang B, Zeng Z, Shi Y.   +6 more
europepmc   +1 more source

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

Inhibitors of KAT2A Alleviate the Progression of AKI by Alleviating Macrophage Ferritinophagy. [PDF]

Immunotargets Ther
Zuo Z, Gao S, Wang J, Liu Z, Lu Z, Wu H, Huang X, Yang C, Chen J, Liu H, Pan Q, Yang L.   +11 more
europepmc   +1 more source

ESAT-6 Modulates Macrophage Apoptosis in Mycobacterium Tuberculosis via lncNEAT1/miR-125b-5p/TNF-α Pathway. [PDF]

Infect Drug Resist
Abudureheman Z, Gong H, Axirejiang T, Xu J, Abuduwake A, Alimu A, Mamuti M, Zheng A, Li L.   +8 more
europepmc   +1 more source