Results 291 to 300 of about 1,540,630 (392)

Novel Drug‐Testing Platform for Vascular Injury‐induced Intimal Hyperplasia Using a Microphysiological System

Advanced Healthcare Materials, EarlyView.
This study develops a 3D vascular injury model using a microphysiological system that mimics key features of intimal hyperplasia. Antiproliferative drugs reduced VSMC proliferation but worsened endothelialdenudation. A combination of diphenyleneiodonium and quercetin effectively reduced proliferation and migration of VSMC and inflammation while ...
Ungsig Nam, HyeMi Kim, Jeong Ah Kim, Ki‐Hwan Nam, Kye‐Sung Lee, Hwan Hur, Jessie S. Jeon, Ji Yong Bae   +7 more
wiley   +1 more source

TLR4/NF-κB-mediated M1 macrophage polarization contributes to the promotive effects of ETS2 on ulcerative colitis. [PDF]

Eur J Med Res
Liu B, Yu J, Zhang J, Ye W, Yao J.
europepmc   +1 more source

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Synthetic Antiferromagnetic Designer Nanodisks for High‐Performance Magnetic Separation

Advanced Healthcare Materials, EarlyView.
Micromagnetic‐modeling‐based design and scalable fabrication of synthetic antiferromagnet (SAF) magnetic disk particles (MDPs) using sputter deposition enable high‐performance magnetic separation. The SAF MDPs achieve high colloidal stability and magnetic responsiveness and enable efficient magnetic separation, outperforming conventional particles ...
Subas Scheibler, Sebastian Habermann, Alexander Gogos, Santiago Helbig, Lukas R. H. Gerken, Anna L. Neuer, Vera M. Kissling, Michal Krupinski, Mohammad Alinezhadfar, Rowena Crockett, Nico Kummer, Erik M. Mayr, Dieter Süss, Hans J. Hug, Inge K. Herrmann   +14 more
wiley   +1 more source

Mechanistic Insights Into Qidan Yixin Decoction for Diabetic Cardiomyopathy via Macrophage Polarization. [PDF]

J Diabetes Res
Liu Y, Zhang J, Gao W, Han Q, Xue Y, Liu X.   +5 more
europepmc   +1 more source

Biomimetic, Suturable, and Extensible Electrospun Scaffolds for Lower Urinary Tract Surgical Reconstruction

Advanced Healthcare Materials, EarlyView.
Biomimetic, suturable, biodegradable fibrous scaffolds are engineered to mimic the tensile properties of LUT tissue using photocrosslinked 5:5% weight per volume elastin‐like peptide and methacrylated gelatin (5E5G). In vitro, urothelium, smooth muscle, and fibroblast 7 day cytocompatibility is demonstrated.
Renea M. Sturm, Yadi Huo, Felix Yiu, Yimin Gu, Ronak Afshari, Zijian Zhong, Ruby Jimenez, Rebekah Jung, Aljohn Cabuan, Keshav Shukla, Karen Harrison, Judy Su, George E. Aninwene II, Victoria Lee, Mahsa Ghovvati, Kaavian Shariati, Nicholas Jackson, Song Li, Nasim Annabi   +18 more
wiley   +1 more source

Platelet-Rich Fibrin Promotes Osteoblast Recruitment-Associated Periodontal Regeneration via Macrophage Polarization. [PDF]

Stem Cells Int
Xu H, Jing H, Miron RJ, Wang Y, Xu D, Zhang X.   +5 more
europepmc   +1 more source

Pulmonary Delivery of siRNA Anti‐TNFα‐loaded Lipid Nanoparticles for Rapid Recovery in Murine Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
In a murine model of acute lung injury, pulmonary administration of lipid nanoparticles carrying TNFα siRNA enables targeted delivery to immune cells. The study emphasises the importance of optimizing LNP distribution and delivery timing to improve therapeutic outcomes and develop emergency therapies for lung hyperinflammation.
Qinglin Wang, Jihana Achour, Laila Emam, Younes Louaguenouni, Catherine Cailleau, Françoise Mercier‐Nomé, Séverine Domenichini, Claudine Delomenie, Sezen Gul, Juliette Vergnaud, Nicolas Tsapis, Arnaud Mansart, Djillali Annane, Francois Fay, Elias Fattal   +14 more
wiley   +1 more source

The role of macrophages in renal fibrosis and therapeutic prospects. [PDF]

PeerJ
Niu D, Yang JJ, He DF.
europepmc   +1 more source

Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells

Advanced Healthcare Materials, EarlyView.
Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex, Ursula Menzel, Yann Ladner, Angela R. Armiento, Martin J. Stoddart   +4 more
wiley   +1 more source