Results 331 to 340 of about 1,540,630 (392)

Suppressing t(4;11) Acute Leukemia by Lipopolymer Nanoparticle Delivery of siRNA Targeting KMT2A::AFF1 with Enhanced Extrahepatic Delivery

Advanced Healthcare Materials, EarlyView.
This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah, Remant KC, Amarnath Praphakar Rajendran, Saba Abbasi Dezfouli, Cezary Kucharski, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Olaf Heidenreich, Hasan Uludağ   +9 more
wiley   +1 more source

Macrophages in chronic infections: regulation and remodeling. [PDF]

Front Immunol
Cui H, Wang M, Jiao S, Tian S, Liu H, Luo B.   +5 more
europepmc   +1 more source

Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun, Elizabeth S. Nakasone, Ha Eun Shin, Hyojin Lee, Jong‐Chan Park, Wonhwa Lee, Wooram Park, Chun Gwon Park, Juwon Park, Se‐Na Kim   +9 more
wiley   +1 more source

Lithium-doped calcium silicate scaffolds-activated M2-polarized macrophage-derived miR-145-5p-riched extracellular vesicles to enhance osteoimmunomodulation for accelerating bone regeneration. [PDF]

J Nanobiotechnology
Kuo TY, Lin TL, Lin YH, Chen CY, Cho DY, Chen YW, Shie MY.   +6 more
europepmc   +1 more source

Coordinated Development of Immune Cell Populations in Vascularized Skin Organoids from Human Induced Pluripotent Stem Cells

Advanced Healthcare Materials, EarlyView.
Vascularized skin organoids are developed from human induced pluripotent stem cells and contain macrophages, Langerhans cells, and neutrophils. Vascularized skin organoids offer a transformative platform to model skin biology and enable mechanistic investigations of inflammatory and hematologic skin disorders.
Mitchell Mostina, Jane Sun, Seen Ling Sim, Imaan A. Ahmed, Fernando Souza‐Fonesca‐Guimaraes, Ernst J. Wolvetang, Jason Brown, Snehlata Kumari, Kiarash Khosrotehrani, Abbas Shafiee   +9 more
wiley   +1 more source

CCR2 and TLR3: noninvasive macrophage-associated biomarkers of acute renal transplant rejection. [PDF]

Ren Fail
Wang S, Pan X, Peng J, Wu M, Zhan X, Wang W, Zhu G, An N, Pei J.   +8 more
europepmc   +1 more source

The inhibitory effect of M2 macrophage-derived exosomes on gefitinib resistant lung adenocarcinoma cells through the MIF/TIMP1/CD74 axis. [PDF]

Sci Rep
Peng J, Zhang Y, Li B, He X, Ding C, Hu W.   +5 more
europepmc   +1 more source

Macrophage transfer promotes intestinal mucosal healing by encouraging transit-amplifying cell expansion in mice. [PDF]

Front Immunol
Kang DS, Song YM, Park YJ, Jeong HJ, Hong JJ, Seok SH, Na YR.   +6 more
europepmc   +1 more source