A cardinal role for cathepsin D in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci [PDF]
, 2011 The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1.
Bewley, M.A. +10 more
core +4 more sources
Ursolic acid enhances macrophage autophagy and attenuates atherogenesis [PDF]
, 2016 Macrophage autophagy has been shown to be protective against atherosclerosis. We previously discovered that ursolic acid (UA) promoted cancer cell autophagy.
Fan, Daping +7 more
core +2 more sources
Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis [PDF]
, 2017 Macrophages specialize in removing lipids and debris present in the atherosclerotic plaque. However, plaque progression renders macrophages unable to degrade exogenous atherogenic material and endogenous cargo including dysfunctional proteins and ...
Ali, Sahl +19 more
core +2 more sources
Antimycobacterial Effect of Selenium Nanoparticles on Mycobacterium tuberculosis
Frontiers in Microbiology, 2020 Tuberculosis (TB) remains the leading cause of death from a single infection agent worldwide. In recent years, the occurrence of TB cases caused by drug-resistant strains has spread, and is expected to continue to grow.
Hector Estevez +10 more
doaj +1 more source
The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases. [PDF]
, 2015 The systemic and organ-specific human fibrotic disorders collectively represent one of the most serious health problems world-wide causing a large proportion of the total world population mortality.
Ballater R +32 more
core +2 more sources
Macrophages in xenotransplantation [PDF]
Korean Journal of Transplantation, 2019 Xenotransplantation refers to organ transplantation across species. Immune rejection of xenografts is stronger and faster than that of allografts because of significant molecular differences between species. Recent studies have revealed the involvement of macrophages in xenograft and allograft rejections.
openaire +4 more sources
MAP kinase phosphatase 2 regulates macrophage-adipocyte interaction. [PDF]
PLoS ONE, 2015 Inflammation is critical for the development of obesity-associated metabolic disorders. This study aims to investigate the role of mitogen-activated protein kinase phosphatase 2 (MKP-2) in inflammation during macrophage-adipocyte interaction.White ...
Huipeng Jiao, Peng Tang, Yongliang Zhang
doaj +1 more source
Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland [PDF]
, 2016 Macrophages are important regulators of branching morphogenesis during development and postnatally in the mammary gland. Regulation of macrophage dynamics during these processes can therefore have a profound impact on development.
Cairney, Claire J. +7 more
core +1 more source
A new lipid-structured model to investigate the opposing effects of LDL and HDL on atherosclerotic plaque macrophages [PDF]
arXiv, 2022 Atherosclerotic plaques form in artery walls due to a chronic inflammatory response driven by lipid accumulation. A key component of the inflammatory response is the interaction between monocyte-derived macrophages and extracellular lipid. Although concentrations of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles in the blood
arxiv
HDL and plaque regression in a multiphase model of early atherosclerosis [PDF]
, 2023 Atherosclerotic plaques are accumulations of cholesterol-engorged macrophages in the artery wall. Plaque growth is initiated and sustained by the deposition of low density lipoproteins (LDL) in the artery wall. High density lipoproteins (HDL) counterbalance the effects of LDL by accepting cholesterol from macrophages and removing it from the plaque. In
arxiv +1 more source