Results 101 to 110 of about 1,150,963 (313)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Alternative Activation of Macrophages: Concepts and Prospects

, 2014
Macrophages of the body represent a widely dispersed, versatile, and highly responsive homeostatic and defense system. They contribute to innate as well as adaptive immunity to infection, mediating trophic as well as injurious interactions with their ...
Martinez, Fernando, Laura Helming, Gordon, S, Siamon Gordon, Fernando O. Martinez Estrada, Helming, Laura   +5 more
core   +1 more source

Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages [PDF]

, 2002
During bacterial infections, the balance between resolution of infection and development of sepsis is dependent upon the macrophage response to bacterial products.
Sweet, Matthew J, Foo Y. Liew, Sester, David P, Katryn J. Stacey, Xu, Damo, David P. Sester, Rebecca C. McDonald, David A. Hume, McDonald, Rebecca C, Campbell, Carol C, Stacey, Katryn J, Hume, David A, Liew, Foo Y, Matthew J. Sweet, Carol C. Campbell, Damo Xu   +15 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Immunohistochemical changes of maxillary sinus mucosa with underlying adenomatous polyposis

Patologìâ, 2017
In maxillary sinusitis pathogenesis researchers paid much attention to the role of paranasal sinuses, sinus drainage dysfunctions, mucocyliary transport system disorders in cases of damage of sinuses mucous membranes.
Yu. M. Andreychyn, I. S. Kovalenko
doaj   +1 more source

Protein Kinase C Beta and Delta Isoenzymes Mediate Cholesterol Accumulation in Pma-Activated Macrophages

, 2009
Previously, we showed that PMA activation of human monocyte- derived macrophages stimulates macropinocytosis (i.e., fluid -phase endocytosis) of LDL and transforms these macrophages into foam cells.
LIN, WAN-WAN, 林琬琬
core  

Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL [PDF]

, 2012
Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring the maternal tolerance to the fetus.
Iordanis Navrozoglou, Darius Dian, Antonis Makrigiannakis, Sabine Guenther, Anz, David, Jeschke, Udo, Klaus Friese, Udo Jeschke, Thomas Vrekoussis, Vrekoussis, Thomas, Knabl, Julia, Dian, Darius, Julia Knabl, Bayer, Birgit, Heublein, Sabine, Navrozoglou, Iordanis, Friese, Klaus, Sabine Heublein, Makrigiannakis, Antonis, David Anz, Guenther, Sabine, Birgit Bayer   +21 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Mechanistic study of pre-eclampsia and macrophage-associated molecular networks: bioinformatics insights from multiple datasets

Frontiers in Genetics
BackgroundPre-eclampsia is a pregnancy-related disorder characterized by hypertension and proteinuria, severely affecting the health and quality of life of patients.
Jinfeng Cao, Jinfeng Cao, Jinfeng Cao, Wenxin Jiang, Wenxin Jiang, Wenxin Jiang, Zhe Yin, Zhe Yin, Zhe Yin, Na Li, Na Li, Na Li, Chao Tong, Hongbo Qi, Hongbo Qi, Hongbo Qi   +15 more
doaj   +1 more source