Results 81 to 90 of about 1,417,216 (308)

GRN Activates TNFR2 to Promote Macrophage M2 Polarization Aggravating Mycobacterium Tuberculosis Infection

Frontiers in Bioscience-Landmark
Background: The polarization of macrophages plays a critical role in the immune response to infectious diseases, with M2 polarization shown to be particularly important in various pathological processes.
Bingling Zhang, Lan Xiang, Jun Chen, Jun Zhang, Renliu Dong, Guolun Mo, Feng Wu   +6 more
doaj   +1 more source

A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages [PDF]

, 2017
Macrophages produce genotoxic agents, such as reactive oxygen and nitrogen species, that kill invading pathogens. Here we show that these agents activate the DNA damage response (DDR) kinases ATM and DNA-PKcs through the generation of double stranded ...
Akira, Akira, Alaoui-El-Azher, Amiri, Anand, Bakkenist, Bednarski, Bednarski, Blunt, Bredemeyer, Bredemeyer, Callen, Callén, Chatzinikolaou, Chumduri, Ciccia, Clausen, Cuevas-Ramos, Edelson, Erttmann, Fedor, Floyd, Frank, Frisan, Griffith, Guerra, Guo, Helmink, Helmink, Herrtwich, Hsieh, Huang, Innes, Jackson, Jinadasa, Karo, Kraal, Kuziel, Lamkanfi, Laubach, Lilley, MacMicking, McNab, Mosser, Nathan, Nesić, Nirodi, Nougayrède, Nunes, Okamura, Pollock, Radi, Ritchie, Rogakou, Roth, Rouleau, Schoenborn, Schwab, Sekiguchi, Sherman, Shi, Tamir, Theunissen, von Moltke, Weitzman, Witte, Wu, Zha   +67 more
core   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Role of Breastmilk in Macrophage-Tumour Cell Interactions in Postpartum Breast Cancer

Frontiers in Bioscience-Landmark
Background: Lactation is associated with long-term reduced risk of breast cancer. However, there is a transient increased risk of breast cancer in the 5 to 10 years postpartum and this is associated with a high incidence of metastasis ...
Reza Maleki, Amna Ghith, Hanieh Heydarlou, Luke E Grzeskowiak, Wendy V Ingman   +4 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Dynamic Roles and Expanding Diversity of Adipose Tissue Macrophages in Obesity

Journal of Obesity & Metabolic Syndrome
Adipose tissue macrophages (ATMs) are key regulators of adipose tissue (AT) inflammation and insulin resistance in obesity, and the traditional M1/M2 characterization of ATMs is inadequate for capturing their diversity in obese conditions.
Shindy Soedono, Vivi Julietta, Hadia Nawaz, Kae Won Cho   +3 more
doaj   +1 more source

Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia. [PDF]

, 2019
Cultured mouse peritoneal macrophages release large numbers of ~30-nm cholesterol-rich particles. Here, we show that those particles represent fragments of the plasma membrane that are pulled away and left behind during the projection and retraction of ...
Fong, Loren G, He, Cuiwen, Heizer, Patrick J, Hu, Xuchen, Jiang, Haibo, Jung, Rachel S, Tontonoz, Peter, Tu, Yiping, Weston, Thomas A, Wohlschlegel, James A, Young, Brian D, Young, Stephen G   +11 more
core   +3 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Development of the nanobody display technology to target lentiviral vectors to antigen-presenting cells [PDF]

, 2012
Lentiviral vectors (LVs) provide unique opportunities for the development of immunotherapeutic strategies, as they transduce a variety of cells in situ, including antigen-presenting cells (APCs). Engineering LVs to specifically transduce APCs is required
Breckpot, Karine, De Baetselier, Patrick, De Groeve, Kurt, Dingemans, Jozef, Goyvaerts, Cleo, Heirman, Carlo, Raes, Geert, Reiser, J, Robays, Lander, Thielemans, Kris, Van Lint, Sandra   +10 more
core   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source