Results 61 to 70 of about 1,150,963 (313)

Accumulation of Ym1 and formation of intracellular crystalline bodies in alveolar macrophages lacking heparanase [PDF]

, 2010
Heparanase is a heparan sulfate (HS) degrading endoglucuronidase that has been implicated in cell migration and inflammatory conditions. Here we used mice deficient of heparanase (Hpse−/−) to study the impact of heparanase on airway leukocytes.
Vlodavsky, Israel, Li, Jin-ping, Zcharia, Eyal, Pejler, Gunnar, Jia, Juan, Li, Jin-Ping,, Waern, Ida, Jia, Juan,, Wernersson, Sara, Sveriges lantbruksuniversitet., Waern, Ida,, Pejler, Gunnar,, Wernersson, Sara,, Vlodavsky, Israel,   +13 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

YC-1 induces lipid droplet formation in RAW 264.7 macrophages

, 2017
Background: 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) is a potential anticancer drug that may activate soluble guanylyl cyclase (sGC) and increase the level of cyclic guanosine monophosphate (cGMP).
Tsui, Leo;Chang, Shwu-Fen;Huang, Hsiang-Po;Fong, Tsorng-Harn;Wang, I-Jong, 王一中   +1 more
core   +1 more source

Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo [PDF]

, 2008
Resident macrophages are an integral component of many tissues and are important in homeostasis and repair. This study examines the contribution of resident tissue macrophages to bone physiology.
Chang, M. K., Kuliwaba, J., Fazzalari, N., Maylin, E., Raggatt, Liza-Jane, Kuliwaba, Julia S., Alexander, K., Hume, D., Schroder, Kate, Maylin, Erin R., Alexander, Kylie A., Maylin, E. R., Fazzalari, Nicola L., Raggatt, L. J., Ripoll, V., Alexander, K. A., Ripoll, V. M., Schroder, K., Ripoll, Vera M, Pettit, A., Raggatt, L., Pettit, Allison R., Kuliwaba, J. S., Fazzalari, N. L., Hume, D. A., Hume, David A., Pettit, A. R., Chang, M., Chang, Ming K.   +28 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Memory Macrophages

International Journal of Molecular Sciences, 2022
Immunological memory is a crucial part of the immune defense that allows organisms to respond against previously encountered pathogens or other harmful factors. Immunological memory is based on the establishment of epigenetic modifications of the genome.
Malgorzata Kloc, Jacek Z. Kubiak, Robert Zdanowski, Rafik M. Ghobrial   +3 more
openaire   +2 more sources

Probing Host Pathogen Cross-Talk by Transcriptional Profiling of Both Mycobacterium tuberculosis and Infected Human Dendritic Cells and Macrophages. [PDF]

, 2008
BACKGROUND: Transcriptional profiling using microarrays provides a unique opportunity to decipher host pathogen cross-talk on the global level. Here, for the first time, we have been able to investigate gene expression changes in both Mycobacterium ...
Waddell, Simon, Castagnoli, PR, Mattia Pelizzola (20247), Castagnoli, Paola Ricciardi, Pelizzola Mattia, Foti, M, Maria Foti, Butcher, Philip, Neyrolles, Olivier, Neyrolles, O, Antoine Tanne, Simon J Waddell, Olivier Neyrolles, Pelizzola, M, Tailleux, L, Simon J. Waddell, Antoine Tanne (272975), Philip D Butcher (16047203), Maria Foti (20249), Neil G. Stoker, Stoker Neil G., Waddell, SJ, Tailleux Ludovic, Tailleux, Ludovic, Gicquel, Brigitte, Simon Waddell (4462816), Castagnoli Paola Ricciardi, Brigitte Gicquel, Philip D Butcher, Tanne Antoine, Alessandra Mortellaro (272973), Mortellaro, A, Gicquel Brigitte, Stoker, Neil, Philip D. Butcher, Butcher, PD, Tanne, Antoine, Olivier Neyrolles (72204), Tanne, A, Mortellaro, Alessandra, Paola Ricciardi Castagnoli (16048310), Ludovic Tailleux, Michael Withers (272974), Neyrolles Olivier, Withers Michael, Foti, Maria, Waddell Simon J., Stoker, NG, Michael Withers, Pelizzola, Mattia, Mortellaro Alessandra, Brigitte Gicquel (31454), Ludovic Tailleux (72195), Neil G Stoker (16048313), Alessandra Mortellaro, Neil G Stoker, Foti Maria, Gicquel, B, Butcher Philip D., Withers, M, Mattia Pelizzola, Paola Ricciardi Castagnoli, Withers, Michael, Waddel S.J., Withers M., Neyrolles O., Tanne A., Tailleux L., Foti M., Stoker N.G., Butcher P.D., Pelizzola M., Mortellaro A., Gicquel B., Castagnoli P.R.   +74 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source