Results 131 to 140 of about 1,818,468 (377)

Decoding multicellular interaction networks–a new horizon in tumor microenvironment research

Molecular Oncology, EarlyView.
Cells in the tumor microenvironment influence tumor establishment and progression through an elaborate array of cellular interactions. Integrating transcriptomic, spatial, and intercellular crosstalk data at single‐cell resolution unveil complex, functionally distinct multicellular circuits.
Roi Balaban, Merav Cohen
wiley   +1 more source

M-1/M-2 Macrophages and the Th1/Th2 Paradigm1

Journal of Immunology, 2000
Evidence is provided that macrophages can make M-1 or M-2 responses. The concept of M-1/M-2 fomented from observations that macrophages from prototypical Th1 strains (C57BL/6, B10D2) are more easily activated to produce NO with either IFN-γ or LPS than ...
C. Mills, K. Kincaid, Jennifer M. Alt, M. Heilman, Annette M Hill   +4 more
semanticscholar   +1 more source

The monocyte-macrophage axis in the intestine [PDF]

, 2014
Macrophages are one of the most abundant leucocytes in the intestinal mucosa where they are essential for maintaining homeostasis. However, they are also implicated in the pathogenesis of disorders such as inflammatory bowel disease (IBD), offering ...
Ajami, Allan McI Mowat, Anthony, Auffray, Auffray, Bain, Bain, Bogunovic, Burke, Calum C. Bain, Carlin, Cerovic, Chang, Chen, Chieppa, Chorro, de Schoolmeester, Denning, Denning, Diehl, Dunay, Fogg, Gautier, Geissmann, Glocker, Grainger, Greter, Grimm, Griseri, Guilliams, Hadis, Hapfelmeier, Hashimoto, Hettinger, Hirotani, Hoeffel, Hoshi, Hou, Ingersoll, Jakubzick, Jenkins, Kamada, Kayama, Kim, Kim, Kinnebrew, Kuhn, Kurihara, Lampinen, Landsman, MacDonald, MacDonald, Maheshwari, McDole, Medina-Contreras, Morrison, Mowat, Muller, Murai, Niess, Niess, Pabst, Passlick, Pavli, Persson, Platt, Pull, Rani, Rescigno, Rivollier, Roberts, Rogler, Rugtveit, Rugtveit, Rydström, Satpathy, Satpathy, Schlitzer, Schreiber, Schulthess, Schulz, Schulz, Serbina, Shaw, Siddiqui, Smith, Smythies, Smythies, Smythies, Sunderkotter, Takada, Takeda, Tamoutounour, Tamoutounour, Tarling, Thiesen, Ueda, van Furth, Varol, Varol, Waddell, Wang, Weber, Yona, Ziegler-Heitbrock, Zigmond   +105 more
core   +2 more sources

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

The Biophysical Micro-Environment's Influence on Cell Fate Decisions During Macrophage Activation and Somatic Cell Reprogramming [PDF]

arXiv, 2020
Cells are known to sense and respond to their mechanical microenvironment in profound ways. Various evidence has implicated the adhesome, a body of adhesion associated proteins, in several cell fate decisions, including differentiation and proliferation.
arxiv  

Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity [PDF]

, 2019
Macrophages resident in different organs express distinct genes, but understanding how this diversity fits into tissue-specific features is limited. Here, we show that selective expression of coagulation factor V (FV) by resident peritoneal macrophages ...
Broze, George J, Cleuren, Audrey C, Czepielewski, Rafael S, Edelson, Brian T, Erlich, Emma C, Esaulova, Ekaterina, Grover, Steven P, Jarjour, Nicholas N, Mackman, Nigel, Randolph, Gwendalyn J, Saunders, Brian T, Zhang, Nan, Zinselmeyer, Bernd H   +12 more
core   +1 more source

Delay of phagosome maturation by a mycobacterial lipid is reversed by nitric oxide.

, 2008
Mycobacterium tuberculosis is a facultative intracellular pathogen that inhibits phagosome maturation in macrophages thereby securing survival and growth.
Axelrod, Sofia, Brinkmann, Volker, Enders, Jana, Haas, Albert, Kaufmann, Stefan HE, Oschkinat, Hartmut, Schaible, Ulrich E, Schlegel, Brigitte   +7 more
core   +1 more source

Multiplex single‐cell profiling of putative cancer stem cell markers ALDH1, SOX9, SOX2, CD44, CD133 and CD15 in endometrial cancer

Molecular Oncology, EarlyView.
Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien, Marta E. Hjelmeland, Hege F. Berg, Rose M. Gold, Kathrine Woie, Lars A. Akslen, Ingfrid S. Haldorsen, Camilla Krakstad   +7 more
wiley   +1 more source

Treating Macrophages with Anti-inflammatory Nanoparticles as a Strategy to Improve Muscle Repair [PDF]

, 2019
The macrophage is an immune cell that is involved in host defense. More recent research, however, has revealed that they also play a central role in mediating the skeletal muscle regenerative process.
Yan, Derek
core   +1 more source

Evaluation of tumor vascularization and microenvironment in follicular lymphoma

Терапевтический архив, 2013
AIM: To characterize the degree of follicular lymphoma (FL) vascularization and microenvironment by immunohistochemical studies (IHCS) of lymph node biopsy paraffin-embedded sections in 2 different disease pattern groups/MATERIAL AND METHODS: The ...
E S Nesterova, S K Kravchenko, É G Gemdzhian, E A Osmanov, A M Kovrigina   +4 more
doaj