Results 161 to 170 of about 1,818,468 (377)

Gene Transfer of Calcitonin Gene-Related Peptide Inhibits Macrophages and Inflammatory Mediators in Vein Graft Disease [PDF]

open access: yes, 2008
Vein graft disease is a chronic inflammatory disease and limits the late results of coronary revascularization. Calcitonin gene-related peptide (CGRP) inhibits macrophages infiltrated and inflammatory mediators, we hypothesized that transfected CGRP gene
Hongsui Wu   +8 more
core   +1 more source

Immunomodulatory Effects of the Neuropeptide Pituitary Adenylate Cyclase-Activating Polypeptide in Acute Toxoplasmosis

open access: yesFrontiers in Cellular and Infection Microbiology, 2019
Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) is an endogenous neuropeptide with distinct functions including the regulation of inflammatory processes.
Caio Andreeta Figueiredo   +9 more
doaj   +1 more source

MIF as an oncogenic driver of low‐heterogeneity melanomas

open access: yesMolecular Oncology, EarlyView.
Shvefel and colleagues identified tumor‐secreted macrophage migration inhibitory factor (MIF) as an upregulated cytokine that mediates immune resistance in melanomas with low‐intratumoral heterogeneity. MIF and its functional paralogue D‐dopachrome tautomerase (D‐DT or MIF‐2) have overlapping but nonidentical signaling functions and are hypothesized to
Thuy T. Tran   +4 more
wiley   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

Tumor-associated CD19$^+$ macrophages induce immunosuppressive microenvironment in hepatocellular carcinoma [PDF]

open access: yesarXiv
Tumor-associated macrophages are a key component that contributes to the immunosuppressive microenvironment in human cancers. However, therapeutic targeting of macrophages has been a challenge in clinic due to the limited understanding of their heterogeneous subpopulations and distinct functions. Here, we identify a unique and clinically relevant CD19$^
arxiv  

Analysis of a mathematical model for interactions between T cells and macrophages [PDF]

open access: yesarXiv, 2010
The aim of this paper is to carry out a mathematical analysis of a system of ordinary differential equations introduced by R. Lev Bar-Or to model the interactions between T cells and macrophages. Under certain restrictions on the parameters of the model, theorems are proved about the number of stationary solutions and their stability. In some cases the
arxiv  

The complex role of tumor-infiltrating macrophages

open access: yesNature Immunology, 2022
A. Christofides   +5 more
semanticscholar   +1 more source

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