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2011
Macrophages are a diverse phenotype of professional phagocytic cells derived from bone-marrow precursors and parent monocytes in the peripheral blood. They are essential for the maintenance and defence of host tissues, doing so by sensing and engulfing particulate matter and, when necessary, initiating a pro-inflammatory response.
Chris P, Verschoor +2 more
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Macrophages are a diverse phenotype of professional phagocytic cells derived from bone-marrow precursors and parent monocytes in the peripheral blood. They are essential for the maintenance and defence of host tissues, doing so by sensing and engulfing particulate matter and, when necessary, initiating a pro-inflammatory response.
Chris P, Verschoor +2 more
openaire +2 more sources
CRC Critical Reviews in Toxicology, 1979
Multinucleated giant cells are commonly found in a wide variety of inflammatory reactions. They are formed at sites of tissue injury by fusion of freshly exuded monocytes, the rate of fusion being dependent on a range of extracellular and intracellular factors.
John M. Papadimitriou +2 more
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Multinucleated giant cells are commonly found in a wide variety of inflammatory reactions. They are formed at sites of tissue injury by fusion of freshly exuded monocytes, the rate of fusion being dependent on a range of extracellular and intracellular factors.
John M. Papadimitriou +2 more
openaire +2 more sources
BioEssays, 1995
AbstractThe macrophage plays an important role in host development and physiology, and in pathogenesis of many infectious, immunologic and degenerative disease processes. It displays marked heterogeneity of phenotype in different tissues, reflecting local interactions with other cell types, and contributes to host homeostasis through a varied ...
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AbstractThe macrophage plays an important role in host development and physiology, and in pathogenesis of many infectious, immunologic and degenerative disease processes. It displays marked heterogeneity of phenotype in different tissues, reflecting local interactions with other cell types, and contributes to host homeostasis through a varied ...
openaire +2 more sources
Macrophage inflammatory protein 1 modulates macrophage function
The Journal of Immunology, 1992Abstract Macrophage inflammatory protein 1 (MIP 1), initially purified from the conditioned medium of endotoxin-stimulated macrophages, is a low m.w. heparin-binding protein doublet comprising two peptides, MIP 1 α and MIP 1 β. Although native doublet MIP 1 has previously been shown to exert pyrogenic, mitogenic, and proinflammatory ...
T J, Fahey +7 more
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Pathophysiology of Haemostasis and Thrombosis, 1984
Monocytes and macrophages can be induced to produce tissue factor. Recent data suggest that macrophages make other products involved in the extrinsic coagulation pathway. These include vitamin K-dependent factors, factor X activators and a prothrombinase.
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Monocytes and macrophages can be induced to produce tissue factor. Recent data suggest that macrophages make other products involved in the extrinsic coagulation pathway. These include vitamin K-dependent factors, factor X activators and a prothrombinase.
openaire +2 more sources
Macrophages as tools and targets in cancer therapy
Nature Reviews Drug Discovery, 2022Alberto Mantovani +2 more
exaly
Clinical relevance of tumour-associated macrophages
Nature Reviews Clinical Oncology, 2022Mikael J Pittet +2 more
exaly
Tissue-specific macrophages: how they develop and choreograph tissue biology
Nature Reviews Immunology, 2023Elvira Mass +2 more
exaly