Results 161 to 170 of about 25,181 (186)
Some of the next articles are maybe not open access.
Revealing macropinocytosis using nanoparticles
Molecular Aspects of Medicine, 2022Endocytosis mechanisms are one of the methods that cells use to interact with their environments. Endocytosis mechanisms vary from the clathrin-mediated endocytosis to the receptor independent macropinocytosis. Macropinocytosis is a niche of endocytosis that is quickly becoming more relevant in various fields of research since its discovery in the ...
Nicolas Means +4 more
openaire +2 more sources
Macropinocytosis: mechanisms and regulation
Biochemical Journal, 2023Macropinocytosis is defined as an actin-dependent but coat- and dynamin-independent endocytic uptake process, which generates large intracellular vesicles (macropinosomes) containing a non-selective sampling of extracellular fluid. Macropinocytosis provides an important mechanism of immune surveillance by dendritic cells and macrophages, but also ...
Gilbert Salloum +2 more
openaire +2 more sources
Trends in Cell Biology, 1995
Macropinocytosis is a form of endocytosis that accompanies cell surface ruffling. It is distinct in many ways from the better characterized micropinocytosis, which includes clathrin-coated vesicle endocytosis and small uncoated vesicles. Because macropinosomes are relatively large, they provide an efficient route for non-selective endocytosis of solute
Swanson, Joel A., Watts, Colin
openaire +3 more sources
Macropinocytosis is a form of endocytosis that accompanies cell surface ruffling. It is distinct in many ways from the better characterized micropinocytosis, which includes clathrin-coated vesicle endocytosis and small uncoated vesicles. Because macropinosomes are relatively large, they provide an efficient route for non-selective endocytosis of solute
Swanson, Joel A., Watts, Colin
openaire +3 more sources
Macropinocytosis: Blowing bubbles
Current Biology, 2023Macropinocytosis is a form of endocytosis in which cells engulf relatively large quantities of extracellular fluid through cup-shaped invaginations of the plasma membrane. New work shows that macropinosome closure occurs without a localized constriction of actin filaments, indicating that membrane tension drives cup closure.
openaire +2 more sources
NRF2 activates macropinocytosis upon autophagy inhibition
Cancer Cell, 2021Su et al. demonstrate that upon inhibiting autophagy, an intracellular nutrient recycling pathway, pancreatic ductal adenocarcinoma cells upregulate NRF2-mediated transcription of macropinocytosis pathway components, thereby triggering an alternate route for tumors to scavenge nutrients from extracellular sources.
Gourish, Mondal, Jayanta, Debnath
openaire +2 more sources
The cytoskeleton in phagocytosis and macropinocytosis
Current Biology, 2021Cells of the innate immune system, notably macrophages, neutrophils and dendritic cells, perform essential antimicrobial and homeostatic functions. These functions rely on the dynamic surveillance of the environment supported by the formation of elaborate membrane protrusions.
Sivakami, Mylvaganam +2 more
openaire +2 more sources
Functional Diversity of Macropinocytosis
2022Eukaryotic cells are capable of internalizing different types of cargo by plasma membrane ruffling and forming vesicles in a process known as endocytosis. The most extensively characterized endocytic pathways are clathrin-coated pits, lipid raft/caveolae-mediated endocytosis, phagocytosis, and macropinocytosis.
Rajeev, Mishra +3 more
openaire +2 more sources
Macropinocytosis: Biology and mechanisms
Cells & Development, 2021Macropinocytosis is a form of endocytosis performed by ruffles and cups of the plasma membrane. These close to entrap droplets of medium into micron-sized vesicles, which are trafficked through the endocytic system, their contents digested and useful products absorbed.
openaire +2 more sources
The Amoebal Model for Macropinocytosis
2022Macropinocytosis is a relatively unexplored form of large-scale endocytosis driven by the actin cytoskeleton. Dictyostelium amoebae form macropinosomes from cups extended from the plasma membrane, then digest their contents and absorb the nutrients in the endo-lysosomal system.
Robert R, Kay +5 more
openaire +2 more sources