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Virus entry by macropinocytosis
Nature Cell Biology, 2009As obligatory intracellular parasites, viruses rely on host-cell functions for most aspects of their replication cycle. This is born out during entry, when most viruses that infect vertebrate and insect cells exploit the endocytic activities of the host cell to move into the cytoplasm.
Mercer J, Helenius A.
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Phosphoinositides in phagocytosis and macropinocytosis
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015Professional phagocytes provide immunoprotection and aid in the maintenance of tissue homeostasis. They perform these tasks by recognizing, engulfing and eliminating pathogens and endogenous cell debris. Here, we examine the paramount role played by phosphoinositides in phagocytosis and macropinocytosis, two major endocytic routes that mediate the ...
Roni, Levin +2 more
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KRASG12R-Independent Macropinocytosis in Pancreatic Cancer
2022Macropinocytosis is a critical route of nutrient acquisition in pancreatic cancer cells. Constitutive macropinocytosis is promoted by mutant KRAS, which activates the PI3Kα lipid kinase and RAC1, to drive membrane ruffling, macropinosome uptake and processing. However, our recent study on the KRASG12R mutant indicated the presence of a KRAS-independent
G Aaron, Hobbs, Channing J, Der
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Macropinocytosis: Insights from immunology and cancer
Current Opinion in Cell Biology, 2020Macropinocytosis is increasingly recognized for its versatile adaptations and functions as a highly conserved, ubiquitous pathway for the bulk uptake of fluid, particulate cargo, and membranes. Innate immune cells and transformed cancer cells share the capacity for both constitutive and induced macropinocytosis, which is used for immune surveillance ...
Jennifer L. Stow, Yu Hung, Adam A. Wall
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Roles for 3’ Phosphoinositides in Macropinocytosis
2022The distinct movements of macropinosome formation and maturation have corresponding biochemical activities which occur in a defined sequence of stages and transitions between those stages. Each stage in the process is regulated by variously phosphorylated derivatives of phosphatidylinositol (PtdIns) which reside in the cytoplasmic face of the membrane ...
Joel A, Swanson, Nobukazu, Araki
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Macropinocytosis in Phagocyte Function and Immunity
2022Phagocytes play critical roles in the maintenance of organismal homeostasis and immunity. Central to their role is their ability to take up and process exogenous material via the related processes of phagocytosis and macropinocytosis. The mechanisms and functions underlying macropinocytosis have remained severely understudied relative to phagocytosis ...
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Quantitation of Macropinocytosis in Cancer Cells
2019Macropinocytosis has emerged as an important nutrient supply pathway that sustains cell growth of cancer cells within the nutrient-poor tumor microenvironment. By internalizing extracellular fluid through this bulk endocytic pathway, albumin is supplied to the cancer cells, which, after degradation, serves as an amino acid source to meet the high ...
Koen M O, Galenkamp +2 more
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Macropinocytosis Supports Cancer Cell Metabolism
Cancer Discovery, 2013Abstract Internalization and degradation of extracellular protein supplies cancer cells with amino acids.
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