Active Macropinocytosis, Lipid Catabolism, and Exhausting Immune Microenvironment of Ascites Tumor Cells Are Involved in Resistance to Platinum‐Based Therapy in Patients With High‐Grade Serous Ovarian Cancer [PDF]
MedCommPlatinum resistance remains a clinical challenge in ovarian cancer. Ascites represents an important mediator and a unique tumor microenvironment (TME) for invasion and metastasis.
Ruiqi Zheng +12 more
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Macropinocytosis: Both a Target and a Tool for Cancer Therapy [PDF]
BiomoleculesMacropinocytosis is a non-selective, clathrin-independent endocytic process that facilitates bulk internalization of extracellular fluid and its dissolved components (including proteins, lipids, and nucleotides) through plasma membrane remodeling and the
Manhan Zhao +5 more
doaj +2 more sources
Macropinocytosis fuels osteoclast differentiation in bone-related diseases [PDF]
Journal of Orthopaedic TranslationObjective: Multinucleated osteoclasts are the principal specialised cells responsible for bone resorption, but osteoclastogenesis, the formation of osteoclasts, entails substantial nutrient and bioenergetic demands.
Mengqin Gu +7 more
doaj +2 more sources
Macropinocytosis in Gracilariopsis lemaneiformis (Rhodophyta)
Frontiers in Plant Science, 2023 Macropinocytosis is an endocytic process that plays an important role in animal development and disease occurrence but until now has been rarely reported in organisms with cell walls.
Haihong Chen +12 more
doaj +3 more sources
Coronaviruses Induce Entry-Independent, Continuous Macropinocytosis
mBio, 2014 Macropinocytosis is exploited by many pathogens for entry into cells. Coronaviruses (CoVs) such as severe acute respiratory syndrome (SARS) CoV and Middle East respiratory syndrome CoV are important human pathogens; however, macropinocytosis during CoV ...
Megan Culler Freeman +4 more
doaj +3 more sources
Visualization of Macropinocytosis in Prostate Fibroblasts [PDF]
Bio-Protocol, 2019 Macropinocytosis has emerged as an important mechanism for non-selective route to internalize extracellular fluids and dissolved molecules in eukaryotic cell.
Rajeev Mishra, Neil Bhowmick
doaj +3 more sources
Apical size reduction by macropinocytosis alleviates tissue crowding [PDF]
Nature CommunicationsTissue crowding represents a critical challenge to epithelial tissues, which often respond via the irreversible process of live cell extrusion. We report that apical size reduction via macropinocytosis serves as a malleable and less destructive form of ...
Enzo Bresteau +11 more
doaj +2 more sources
Macropinocytosis Exploitation by Cancers and Cancer Therapeutics [PDF]
Frontiers in Physiology, 2016 Macropinocytosis has long been known as a primary method for cellular intake of fluid-phase and membrane-bound bulk cargo. This review seeks to re-examine the latest studies to emphasize how cancers exploit macropinocytosis to further their tumorigenesis,
Kevin D Ha +2 more
doaj +3 more sources
PKCα Phosphorylates FACI to Switch Its Function in Clathrin-mediated Endocytosis to a Presumed Role in Macropinocytosis in Intestinal and Hepatic CellsSummary [PDF]
Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: We previously identified a fasting- and CREB-H-induced (FACI) protein and defined its adaptor function in clathrin-mediated endocytosis. Both CREB-H and FACI are specifically expressed in the liver and intestine.
Yun Cheng +4 more
doaj +2 more sources
Macropinocytosis: a pathway to protozoan infection [PDF]
Frontiers in Physiology, 2015 Among the various endocytic mechanisms in mammalian cells, macropinocytosis involves internalization of large amounts of plasma membrane together with extracellular medium, leading to macropinosome formation.
Tecia Maria Ulisses Carvalho +3 more
doaj +3 more sources