Results 21 to 30 of about 25,181 (186)
WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity [PDF]
Nature CommunicationsTissue-resident macrophages (TRM) are critical for mammalian organismal development and homeostasis. Here we report that with-no-lysine 1 (WNK1) controls myeloid progenitor fate, with Csf1r iCre-mediated Wnk1 deletion in mice (WNK1-deficient mice ...
Alissa J. Trzeciak +23 more
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Research Progress of Macropinocytosis in Digestive System Tumors
Zhongliu Fangzhi Yanjiu, 2023 Macropinocytosis, an evolutionarily conserved, actin-dependent form of endocytosis, is involved in various physiological processes, including nutrient absorption, antigen presentation, and cell signaling transduction and migration.
CHEN Ting +4 more
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Frontiers in Oncology, 2021 Macropinocytosis is an important mechanism of internalizing extracellular materials and dissolved molecules in eukaryotic cells. Macropinocytosis has a dual effect on cancer cells.
Shaojuan Song +4 more
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Defining Macropinocytosis [PDF]
Traffic, 2009 Macropinocytosis represents a distinct pathway of endocytosis in mammalian cells. This actin‐driven endocytic process is not directly co‐ordinated by the presence of cargo but can be induced upon activation of growth factor signalling pathways. The capacity to dissect the contribution of macropinocytosis to cellular processes has been hampered by a ...
Kerr, M. C., Teasdale, R. D.
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A Leep1 into migration and macropinocytosis [PDF]
Journal of Cell Biology, 2021 Actin organization underpins conserved functions at the leading edge of cells. In this issue, Yang et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202010096) characterize Leep1 as a bi-functional regulator of migration and macropinocytosis through PIP3 and the Scar/WAVE complex.
Yvette W.H. Koh, Jennifer L. Stow
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Journal of Experimental & Clinical Cancer Research, 2022 Background Macropinocytosis, an important nutrient-scavenging pathway in certain cancer cells, allows cells to compensate for intracellular amino acid deficiency under nutrient-poor conditions.
Jun-Kyu Byun +9 more
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Piezo1 activation using Yoda1 inhibits macropinocytosis in A431 human epidermoid carcinoma cells
Scientific Reports, 2022 Macropinocytosis is a type of endocytosis accompanied by actin rearrangement-driven membrane deformation, such as lamellipodia formation and membrane ruffling, followed by the formation of large vesicles, macropinosomes.
Masashi Kuriyama +8 more
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Macropinocytosis Fuels Prostate Cancer [PDF]
Cancer Discovery, 2018 Abstract Summary: Kim and colleagues identify necrotic debris as a macropinocytic cargo in PTEN-deficient prostate cancer cells, which is catabolized to generate the nutrients and biomass necessary to support tumor cell growth and metabolism in nutrient-limiting conditions. Cancer Discov; 8(7); 800–2. ©2018 AACR.
Cosimo, Commisso, Jayanta, Debnath
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Macropinocytosis in Different Cell Types: Similarities and Differences
Membranes, 2020 Macropinocytosis is a unique pathway of endocytosis characterised by the nonspecific internalisation of large amounts of extracellular fluid, solutes and membrane in large endocytic vesicles known as macropinosomes.
Xiao Peng Lin +2 more
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Ubiquitous macropinocytosis in anthozoans
eLife, 2020 Transport of fluids, molecules, nutrients or nanoparticles through coral tissues are poorly documented. Here, we followed the flow of various tracers from the external seawater to within the cells of all tissues in living animals. After entering the general coelenteric cavity, we show that nanoparticles disperse throughout the tissues via the ...
Philippe Ganot +5 more
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