Results 31 to 40 of about 25,181 (186)
The Role and Therapeutic Potential of Macropinocytosis in Cancer
Frontiers in Pharmacology, 2022 Macropinocytosis, a unique endocytosis pathway characterized by nonspecific internalization, has a vital role in the uptake of extracellular substances and antigen presentation.
Zejing Qiu +41 more
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SNAT7 regulates mTORC1 via macropinocytosis
Proceedings of the National Academy of Sciences, 2022 Significance The mammalian target of rapamycin complex 1 (mTORC1) signaling pathway is frequently elevated in human disease, including cancer, type 2 diabetes, metabolic disorders, and neurodegeneration. We identify SNAT7 as an important regulator of mTORC1.
Delong Meng +13 more
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Frontiers in Physiology, 2015 Dendritic cells (DCs) are outstanding antigen presenting cells (APCs) due to their robust ability to internalize extracellular antigens using endocytic processes such as receptor-mediated endocytosis, phagocytosis, and macropinocytosis.
Zhenzhen eLiu, Paul A. Roche
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The PMA phorbol ester tumor promoter increases canonical Wnt signaling via macropinocytosis
eLife, 2023 Activation of the Wnt pathway lies at the core of many human cancers. Wnt and macropinocytosis are often active in the same processes, and understanding how Wnt signaling and membrane trafficking cooperate should improve our understanding of embryonic ...
Nydia Tejeda-Munoz +7 more
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Wnt, GSK3, and Macropinocytosis
, 2022 Here we review the regulation of macropinocytosis by Wnt growth factor signaling. Canonical Wnt signaling is normally thought of as a regulator of nuclear β-catenin, but emerging results indicate that there is much more than β-catenin to the Wnt pathway. Macropinocytosis is transiently regulated by EGF-RTK-Ras-PI3K signaling.
Nydia Tejeda-Muñoz +1 more
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Photonics, 2022 Since their invention, confocal microscopy and super-resolution microscopy have become important choices in cell biology research. Macropinocytosis is a critical form of endocytosis.
Linyu Xu +3 more
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Uses and abuses of macropinocytosis [PDF]
Journal of Cell Science, 2016 ABSTRACT Macropinocytosis is a means by which eukaryotic cells ingest extracellular liquid and dissolved molecules. It is widely conserved amongst cells that can take on amoeboid form and, therefore, appears to be an ancient feature that can be traced back to an early stage of evolution.
Gareth Bloomfield, Robert R. Kay
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Macropinocytosis: New Insights Into Its Underappreciated Role in Innate Immune Cell Surveillance
Frontiers in Immunology, 2018 Macropinocytosis has received increasing attention in recent years for its various roles in nutrient acquisition, immune surveillance, and virus and cancer pathologies.
Johnathan Canton
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Macropinocytosis, mTORC1 and cellular growth control [PDF]
Cellular and Molecular Life Sciences, 2017 The growth and proliferation of metazoan cells are driven by cellular nutrient status and by extracellular growth factors. Growth factor receptors on cell surfaces initiate biochemical signals that increase anabolic metabolism and macropinocytosis, an actin-dependent endocytic process in which relatively large volumes of extracellular solutes and ...
Sei Yoshida +3 more
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Macropinocytosis confers resistance to therapies targeting cancer anabolism
Nature Communications, 2020 Macropinocytosis allows cancer cells to cope with nutrient stress. Here, the authors use a selective, genetic approach to inhibit macropinocytosis and show that consuming necrotic cell debris via macropinocytosis—necrocytosis—affords resistance to many ...
Vaishali Jayashankar, Aimee L. Edinger
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