Trehalose extricates impaired mitochondrial and autophagy dysregulation in patient iPSC-derived macular corneal dystrophy disease model [PDF]
Stem Cell Research & TherapyBackground Patient-derived induced pluripotent stem cell (iPSCs) represents a powerful tool for elucidating the underlying disease mechanisms. Macular corneal dystrophy (MCD) is an intractable and progressive bilateral corneal disease affecting the ...
Divyani Nayak +6 more
doaj +3 more sources
Corneal Higher Order Aberrations in Granular, Lattice and Macular Corneal Dystrophies. [PDF]
PLoS ONE, 2016 To evaluate the corneal higher-order aberrations (HOAs) in granular, lattice and macular corneal dystrophies.This retrospective study includes consecutive patients who were diagnosed as granular corneal dystrophy type2 (GCD2; 121 eyes), lattice corneal ...
Yukari Yagi-Yaguchi +5 more
doaj +5 more sources
Effects of aberrant Pax6 gene dosage on mouse corneal pathophysiology and corneal epithelial homeostasis. [PDF]
PLoS ONE, 2011 BackgroundAltered dosage of the transcription factor PAX6 causes multiple human eye pathophysiologies. PAX6⁺/⁻ heterozygotes suffer from aniridia and aniridia-related keratopathy (ARK), a corneal deterioration that probably involves a limbal epithelial ...
Richard L Mort +8 more
doaj +6 more sources
Fenofibrate in ophthalmology: therapeutic efficacy and mechanisms [PDF]
Journal of Pharmacy & Pharmaceutical SciencesOphthalmic diseases are a growing global cause of visual impairment, driven by population aging and the rising prevalence of diabetes mellitus. Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPARα) agonist widely used for dyslipidemia ...
Sean Chung-Hei Ho +7 more
doaj +2 more sources
Macular corneal dystrophy and associated corneal thinning. [PDF]
Eye (Lond), 2014 To identify the molecular genetic cause of macular corneal dystrophy (MCD) in four probands, and characterize phenotypic similarities between MCD and keratoconus.We performed ophthalmological examination, Scheimpflug imaging (Pentacam, Oculus Inc.), histopathological examination of excised corneal buttons, and direct sequencing of the CHST6 coding ...
Dudakova L +8 more
europepmc +4 more sources
Deep anterior lamellar vs penetrating keratoplasty for macular and granular stromal dystrophies: clinical and refractive results [PDF]
BMC OphthalmologyBackground To evaluate and compare visual, refractive, and keratometric outcomes and complications in patients who underwent Deep Anterior Lamellar Keratoplasty (DALK) and Penetrating Keratoplasty (PKP) surgery for stromal corneal dystrophies.
Cem Sari +5 more
doaj +2 more sources
Roles of matrix metalloproteinases in the cornea: A special focus on macular corneal dystrophy
Medicine in Drug Discovery, 2021 Matrix metalloproteinases (MMPs) are endopeptidases that are responsible for the degradation of several components of the extracellular matrix (ECM) and some non-ECM proteins.
Saniye Gul Kaya +5 more
doaj +3 more sources
Visual and Refractive Outcomes of Different Bubble Types in Deep Anterior Lamellar Keratoplasty for Macular Corneal Dystrophy [PDF]
Journal of Current OphthalmologyPurpose: To determine the variations in deep anterior lamellar keratoplasty (DALK) techniques in eyes with macular corneal dystrophy (MCD), and to compare visual outcomes between standard DALK and Descemet’s membrane (DM) baring DALK.
Mohamed Bahgat Goweida +3 more
doaj +2 more sources
Bridging Mechanism and Therapy in Ocular Disease: Mitochondrial, Vascular, and Immune Pathways in the Eye [PDF]
LifeThere is an increasing global burden of ocular disorders, with an estimated 43.3 million people worldwide currently blind and a further 295 million living with moderate-to-severe vision impairment, driven by a complex pathogenesis that involves multiple ...
Sheryene Tejeda +3 more
doaj +2 more sources
Simultaneous Presence of Macular Corneal Dystrophy and Retinitis Pigmentosa in Three Members of a Family [PDF]
Iranian Journal of Medical Sciences, 2018 Macular corneal dystrophy (MCD) is an autosomal recessive hereditary disease. In most cases, various mutations in carbohydrate sulfotransferase 6 (CHST6) gene are the main cause of MCD.
Farhad Nejat +4 more
doaj +1 more source