Results 31 to 40 of about 212,972 (185)

Advancing Treatment of Degenerative Eye Diseases at the Nanoscale. [PDF]

Smart Med
Nanotherapeutics possess the potential to overcome longstanding bottlenecks in treating degenerative ophthalmic diseases. With a highly tunable surface chemistry, nanotechnology platforms can be customized to navigate specific anatomical barriers in the eye and target pathways of diseases.
Yao Jin L, Selvam EGP, Mei Q, Luu CD, Yap YHY, Teh DBL.   +5 more
europepmc   +2 more sources

Macular Corneal Dystrophy: An Updated Review

Current Eye Research, 2020
Macular Corneal Dystrophy is an autosomal recessive form of corneal dystrophy due to a mutation in CHST6 gene, which results in abnormal proteoglycan synthesis. There is accumulation of abnormal glycosaminoglycans in the corneal stroma and endothelium. The deposition results in progressive loss of corneal transparency and visual acuity.
Shalini Singh, Sujata Das, Chitra Kannabiran, Saumya Jakati, Sunita Chaurasia   +4 more
openaire   +2 more sources

Generation of iPSC line (GLNNFi001-A) from peripheral blood mononuclear cells of a patient with macular corneal dystrophy

Stem Cell Research, 2022
Macular corneal dystrophy (MCD) an autosomal recessive disorder leading to severe visual impairment is caused by mutations in the carbohydrate sulfotransferase 6 (CHST6) gene.
Koushik Chakrabarty, K.N. Prashanthi, Rohit Shetty, Shubham Argulwar, Nallathambi Jeyabalan, Arkasubhra Ghosh   +5 more
doaj   +1 more source

Deep anterior lamellar keratoplasty outcomes in macular and granular corneal dystrophy – A comparative cross-sectional study

Indian Journal of Ophthalmology, 2019
Purpose: To compare the functional and anatomical outcomes (in terms of graft uptake and rejection/failure) of deep anterior lamellar keratoplasty (DALK) in stromal corneal dystrophy (macular and granular).
Shreesha Kumar Kodavoor, Bijita Deb, Dandapani Ramamurthy   +2 more
doaj   +1 more source

Post-deep anterior lamellar keratoplasty ectasia in a case of macular corneal dystrophy

Indian Journal of Ophthalmology. Case Reports, 2023
A 30-year-old female presented with diminution of vision in the right eye for 2 months. She was a known case of macular corneal dystrophy and had undergone OD deep anterior lamellar keratoplasty 2 years back. The best corrected visual acuity (BCVA) was 6/
Deepali Singhal, Nimmy Raj, Prafulla K Maharana   +2 more
doaj   +1 more source

Biomaterials used for tissue engineering of barrier-forming cell monolayers in the eye

Frontiers in Bioengineering and Biotechnology, 2023
Cell monolayers that form a barrier between two structures play an important role for the maintenance of tissue functionality. In the anterior portion of the eye, the corneal endothelium forms a barrier that controls fluid exchange between the aqueous ...
Samantha Sasseville, Samantha Sasseville, Samira Karami, Samira Karami, Ange Tchatchouang, Ange Tchatchouang, Pascale Charpentier, Pascale Charpentier, Princia Anney, Princia Anney, Delphine Gobert, Delphine Gobert, Stéphanie Proulx, Stéphanie Proulx   +13 more
doaj   +1 more source

Potential role of extracellular granzyme B in wet age-related macular degeneration and fuchs endothelial corneal dystrophy

Frontiers in Pharmacology, 2022
Age-related ocular diseases are the leading cause of blindness in developed countries and constitute a sizable socioeconomic burden worldwide. Age-related macular degeneration (AMD) and Fuchs endothelial corneal dystrophy (FECD) are some of the most ...
Eden Dubchak, Gideon Obasanmi, Matthew R. Zeglinski, David J. Granville, Sonia N. Yeung, Joanne A. Matsubara   +5 more
doaj   +1 more source

Atypical presentation of macular corneal dystrophy

Indian Journal of Clinical and Experimental Ophthalmology, 2022
A 65-year old male patient presented to our ophthalmology OPD for regular check up. On examination visual acuity of the right eye was 6/24 improving to 6/12p with pinhole and left eye was 6/18 improving with pinhole 6/9. On examination of anterior segment both eyes cornea showed multiple white round deposits at deep posterior stroma and Descemet ...
Priyadarshini Parthasarathi, null Venipriya, Justin Prashanth, Hannah Ranjee Prasanth   +3 more
openaire   +1 more source

Infectious Keratitis: An Update on Role of Epigenetics

Frontiers in Immunology, 2021
Epigenetic mechanisms modulate gene expression and function without altering the base sequence of DNA. These reversible, heritable, and environment-influenced mechanisms generate various cell types during development and orchestrate the cellular ...
Sudhir Verma, Aastha Singh, Akhil Varshney, R. Arun Chandru, Manisha Acharya, Jyoti Rajput, Virender Singh Sangwan, Amit K. Tiwari, Tuhin Bhowmick, Anil Tiwari   +9 more
doaj   +1 more source

Corneal transplantation: Restoring sight to the blind

Acta Ophthalmologica, EarlyView.
Abstract Corneal blindness is one of the leading causes of vision loss worldwide. Transplantation of the cornea can restore vision and make blind patients see again. Corneal transplant surgery has undergone major evolution in recent decades with the advent of minimally invasive lamellar surgical approaches such as DMEK and DALK.
Claus Cursiefen
wiley   +1 more source