Results 181 to 190 of about 511,582 (401)

Senescence Alters Antimicrobial Peptide Expression and Induces Amyloid‐β Production in Retinal Pigment Epithelial Cells

Aging Cell, EarlyView.
Healthy RPE cells produce AMPs and AMP precursors, including amyloid precursor protein (APP) and chemerin, and protect the neuroretina from blood‐borne pathogens and maintain homeostasis. When RPE cells undergo senescence, the antibacterial activity declines, and APP undergoes amylogenesis, leading to Aβ deposition.
Jian Liu, Caijiao Yi, Jinyan Qi, Xuexue Cui, Xiangling Yuan, Wen Deng, Mei Chen, Heping Xu   +7 more
wiley   +1 more source

Intravitreal Aflibercept Outcomes in Patients with Persistent Macular Exudate Previously Treated with Bevacizumab and/or Ranibizumab for Neovascular Age-Related Macular Degeneration

Journal of Ophthalmology, 2014
David R. Griffin, Preston P. Richmond, John C. Olson   +2 more
doaj   +1 more source

Two Cases (Brother and Sister) of Familial Macular Degeneration in Adolescence

, 1935
Humphrey Neame
openalex   +1 more source

Photocoagulation of subfoveal choroidal neovascular membranes in age related macular degeneration: the impact of the macular photocoagulation study in the United Kingdom and Republic of Ireland [PDF]

, 1999
Stephen Beatty, Kah‐Guan Au Eong, D. Scott McLeod, Paul N. Bishop   +3 more
openalex   +1 more source

Age‐Dependent Histone Deacetylase 3 Regulation by βA3/A1‐Crystallin and Inositol Hexaphosphate in Retinal Pigmented Epithelial Cells Reveals a Novel Pathway in Age‐Related Macular Degeneration

Aging Cell, EarlyView.
βA3/A1‐crystallin regulates HDAC3 activity and epigenetic processes in the RPE. (A) The illustration demonstrates that βA3/A1‐crystallin plays a crucial role in maintaining IPMK protein expression, which in turn activates HDAC3. (B) When βA3/A1‐crystallin is absent (Cryba1 KO ), IPMK protein expression decreases, resulting in the deactivation of HDAC3.
Sujan Chatterjee, Sayan Ghosh, Zachary Sin, Vishnu Suresh Babu, Loretta Viera Preval, Emily Davis, Nguyen Tran, Sridhar Bammidi, Pooja Gautam, Stacey Hose, Yuri Sergeev, Miguel Flores‐Bellver, Kevin Ritter, Henning J. Jessen, Issam Al Diri, Debasish Sinha, Prasun Guha   +16 more
wiley   +1 more source

Biomaterial engineering strategies for modeling the Bruch’s membrane in age-related macular degeneration

Neural Regeneration Research
Age-related macular degeneration, a multifactorial inflammatory degenerative retinal disease, ranks as the leading cause of blindness in the elderly. Strikingly, there is a scarcity of curative therapies, especially for the atrophic advanced form of age ...
Blanca Molins, Andrea Rodríguez, Víctor Llorenç, Alfredo Adán   +3 more
doaj   +1 more source

Macular function impairment in eyes with early age-related macular degeneration [PDF]

, 1997
C Degli, Mc Blarzino, M. Valenti, Tatiana Segato, E Mideno   +4 more
openalex   +1 more source

Tracking visual outcomes – Follow‐up on patients born preterm with childhood‐onset visual impairment

Acta Ophthalmologica, EarlyView.
Abstract Purpose Preterm birth is associated with a risk of ocular complications. The primary aim of the study was to evaluate the main cause of visual impairment (VI) in a cohort of preterm born patients who had childhood‐onset VI. The association between health‐related quality of life (HRQoL) and age, cause—and severity of VI and impairment type was ...
Hajer A. Al‐Abaiji, Kamilla Rothe Nissen, Carina Slidsborg, Morten La Cour, Line Kessel   +4 more
wiley   +1 more source

Choroidal changes and association with Gaussian curvature in high myopic eyes with posterior staphyloma in ultra‐wide‐field optical coherence tomography angiography

Acta Ophthalmologica, EarlyView.
Abstract Purpose To evaluate choroidal changes in high myopic (HM) patients with posterior staphyloma (PS) and explore their association with Gaussian curvature (K) using ultra‐wide‐field optical coherence tomography angiography (UWF‐OCTA). Methods HM patients with wide macular PS (Type I PS) and without any PS (control) were recruited.
Qing Zhao, Linxin Wei, Huan Chen, Yan Luo, Youxin Chen, Zhikun Yang   +5 more
wiley   +1 more source

Mutations in the VMD2 gene are associated with juvenile-onset vitelliform macular dystrophy (Best disease) and adult vitelliform macular dystrophy but not age-related macular degeneration [PDF]

, 2000
Franziska Krämer, Karen L. White, Daniel Pauleikhoff, Andrea Gehrig, Lori A. Passmore, Andrea Rivera, Günther Rudolph, Ulrich Kellner, Monika Andrassi, Birgit Lorenz, Klaus Rohrschneider, A. Blankenagel, Bernhard Jurklies, H Schilling, F. Schütt, Frank G. Holz, Bernhard H. F. Weber   +16 more
openalex   +1 more source