Results 201 to 210 of about 285,624 (259)

Short‐Chain Fatty Acids: Microbial Metabolites Driving Gut‐Eye Axis Signaling

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Short‐chain fatty acids generated by gut microbial fermentation link diet to ocular physiology via the gut–eye axis. Through systemic distribution, these metabolites regulate GPCR signaling, epigenetic pathways, inflammation, and angiogenesis, shaping retinal homeostasis and highlighting therapeutic potential in ocular vascular and inflammatory ...
Aleah J. Brokemond, Ronny Amamoo, Fapianey J. Alexandre, Sewedo B. Ajisegiri, Menaka C. Thounaojam, Pamela M. Martin, Ravirajsinh N. Jadeja   +6 more
wiley   +1 more source

Visual Functioning and Progression from Intermediate Age-Related Macular Degeneration (AMD) to Advanced AMD. [PDF]

Ophthalmic Epidemiol
Patel S, de Carlo Forest T, Lisker-Cervantes A, Gnanaraj R, Lynch A, Mandava N, Mathias M, Manoharan N, Patnaik J.   +8 more
europepmc   +1 more source

Mesenchymal Stem Cell‐Derived Extracellular Vesicles Ameliorate NaIO3‐Induced Dry AMD by Delivering miR‐486‐3p to Inhibit Lipocalin‐2‐Mediated Ferroptosis

MedComm, Volume 7, Issue 10, October 2026.
Our study reveals a novel mechanism by which MSC‐derived EVs alleviate NaIO3‐induced dry AMD‐like pathology. MSC‐EVs deliver miR‐486‐3p into retinal cells to directly inhibit the ferroptosis‐promoting target gene Lcn2. Concurrently, downregulated Lcn2 restores intracellular Gpx4 expression, thereby suppressing ferroptosis and rescuing retinal ...
Zheng Li, Tujing Zhao, Lin Ye, Runze Li, Huaping Tian, Ruilin Liao, Lulin Huang   +6 more
wiley   +1 more source

Optical Coherence Tomography Angiography in Age-Related Macular Degeneration. [PDF]

Rom J Ophthalmol
Duculescu AI, Pirvulescu R, Geamanu A, Firinciogullari E, Toma E, Alexandrescu C, Stanca HT.   +6 more
europepmc   +1 more source

What Matters Most: A Case of Pemphigus Vulgaris in a Nonagenarian Physician

Journal of the American Geriatrics Society, EarlyView.
Svetlana Bagdasarov, Loma Dave, Alan Sang, Lisa Zhou, Billie Fyfe‐Kirschner, Ying Guo, Ibiyonu Lawrence   +6 more
wiley   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

Real-world outcomes of faricimab in treatment-naïve patients with neovascular age-related macular degeneration. [PDF]

BMC Ophthalmol
Chang W, Kim J, Jeon J, Park S.
europepmc   +1 more source

DNA Origami Uptake in Y‐79 Retinoblastoma Cells Driven by Oligolysine Coating

Small Structures, Volume 7, Issue 10, October 2026.
We show that polymeric coating can enable DNA origami nanoparticle internalization into ocular retinoblastoma cells. Not only are the coated nanoparticles well‐tolerable to the cells, but they also remain mobile in the vitreous of a porcine ex vivo model.
Anna Klose, Zahra Gounani, Sergei Raik, Artturi Koivuniemi, Sonja Korhonen, Mika Reinisalo, Tatu Lajunen, Veikko Linko, Timo Laaksonen   +8 more
wiley   +1 more source

Correction: Genetic determinants of age-related macular degeneration in Middle Eastern populations: a systematic review. [PDF]

Front Genet
Sannan NS.
europepmc   +1 more source