Results 181 to 190 of about 81,968 (264)

Lack of Differences in the Pharmacokinetics of Therapeutic Monoclonal Antibodies Between Japanese and Non‐Japanese Individuals

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Evaluation of the pharmacokinetics (PK) of new drugs in Japanese individuals is regularly requested by the Japanese regulatory agency prior to participation in global clinical trials or for bridging approaches for regulatory approval. However, the need for PK assessments in the Japanese population may be less compelling for monoclonal ...
Paridhi Gupta, Ashish Sharma, Bernd Meibohm   +2 more
wiley   +1 more source

Visual noise in augmented reality improves vision in age-related macular degeneration. [PDF]

NPJ Aging
Raul P, Lee T, Barry R, Sabeti F, van Boxtel JJA.   +4 more
europepmc   +1 more source

Keratan Sulfate: An Electroconductive Glycosaminoglycan at the Interface of Sensory Perception and Neural Signaling

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Laboratory studies show KS has electroconductive properties with the ability to trap and transport protons in neurotransductive processes (Grotthuss proton shuttling). This maintains electrochemical gradients and fluxes at the neuronal cell surface in neural activation. Such processes are central to neuronal cell signaling and communication.
James Melrose
wiley   +1 more source

Retinal pigment epithelium pathology in age-related macular degeneration: mitigation with melatonin. [PDF]

Front Med (Lausanne)
Reiter RJ, Sharma R, Blasiak J, Rosales-Corral S, Loh D.   +4 more
europepmc   +1 more source

Quantifying Dehydration Effects of Porcine Vocal Fold Attenuation With Optical Coherence Tomography

The Laryngoscope, Volume 136, Issue 8, Page 3519-3526, August 2026.
The purpose of this study is to use optical coherence tomography (OCT) to characterize the effect of dehydration on the optical attenuation coefficient of porcine vocal fold (VF) tissue. The optical attenuation coefficient tissue decreased linearly with dehydration, dropping by approximately 0.08 mm−1 for every 1% increase in mass loss.
Owen P. Wischhoff, Michael Kuang, Brady D. Prosser, Jakob R. Holm, Jack J. Jiang   +4 more
wiley   +1 more source

Reprogramming Glial Cell Metabolism via a tRNA Fragment Preserves Vision in Retinal Neurodegeneration

MedComm, Volume 7, Issue 8, August 2026.
Under oxidative and excitotoxic stress, Müller cell‐derived 5′tiRNA‐His‐GTG contributes to retinal neurodegeneration. Pathological stimuli increase ANG‐dependent production of 5′tiRNA‐His‐GTG, which suppresses LPCAT1 expression and disrupts phosphatidylcholine (PC)‐mediated glycerophospholipid metabolism.
Yuke Ji, Sha Liu, Ying Zhang, Junya Zhu, Chang Huang, Ya Zhao, Jiao Xia, Wan Mu, Jin Yao, Biao Yan   +9 more
wiley   +1 more source

Microperimetry-Based Fixation Training in Patients with Age-Related Macular Degeneration (AMD). [PDF]

J Clin Med
Ciszewska K, Winiarczyk M, Winiarczyk D, Mackiewicz J.   +3 more
europepmc   +1 more source

Injectable Artificial Photoreceptors: STEM Cell Functional Integration and in vivo Electrophysiological Validation in Retinal Degeneration Models

Small Science, Volume 6, Issue 8, August 2026.
Artificial photoreceptors are engineered to efficiently absorb light, with the strongest sensitivity in the green region of the visible spectrum. Upon illumination, they generate electrical signals that activate retinal ganglion cells, which are typically unaffected by disease, enabling transmission of visual information to the brain.
Afshin Izadian, Ali Torkashvand, Benjamin Allan McCall, Yong Gao, Christine M. Taylor, Fateme Karimi Hafshejani, Arupratan Das, Michelle L. Surma, Sunland Gong, Amir Reza Hajrasouliha   +9 more
wiley   +1 more source

TREM2 in age-related macular degeneration: a microglia-centered perspective in the retinal myeloid landscape. [PDF]

Front Ophthalmol (Lausanne)
Zhu S, Yang T, Sheng L, Shi L.
europepmc   +1 more source