Results 141 to 150 of about 450,506 (276)
Optimizing Body Size‐Based Dosing Approaches for Antibody–Drug Conjugates
Clinical Pharmacology &Therapeutics, EarlyView.Optimized dosing precision of antibody–drug conjugates (ADCs) remains challenging due to narrow therapeutic indices, efficacious doses near the maximum tolerated dose, and substantial interindividual variability in exposure. Body size‐based dosing can reduce exposure variability when the allometric scaling exponent for clearance α = 1 but may over‐ or ...
Andrew B. SyBing, Diane D. Wang
wiley +1 more source
Population Pharmacokinetics of Clesrovimab in Preterm and Full‐Term Infants
Clinical Pharmacology &Therapeutics, EarlyView.Clesrovimab is a half‐life extended monoclonal antibody targeting the respiratory syncytial virus fusion protein. Three studies (phase Ib/IIa [MK‐1654‐002], phase IIb/III [CLEVER], and phase III [SMART]) were conducted to evaluate the efficacy, safety, and pharmacokinetics (PK) of clesrovimab in infants.
Ziheng Hu +8 more
wiley +1 more source
Conflict Resolution Quarterly, EarlyView.ABSTRACT Environmental conflicts are increasing as is interest in ways they can be managed. However, evaluations of Environmental Conflict Resolution (ECR) processes based on direct observation remain scarce, despite ECR existing for over half a century.
Callum Leavey‐Wilson +2 more
wiley +1 more source
Dr. Leena Krogerus: A Grand Old Lady of the Finnish Cytopathology and My Cytopathology Mum
Diagnostic Cytopathology, EarlyView.ABSTRACT The communication introduces former President of the Finnish Society of Clinical Cytology and organizer of the European Congress of Cytology in Rovaniemi, Dr. Leena Krogerus. She played an important role in the formation of my cytopathology career as she led my path in cytopathology education, research, and leadership.
Ivana Kholová
wiley +1 more source
Ecography, EarlyView.Published distribution data, while invaluable for understanding species' biogeography, often suffer from limitations such as dated and static representations of ranges, a bias toward latitudinal information, and lack of resolution in sampling frequency and variation in abundance throughout a species' distribution.
Priyanka Soni +2 more
wiley +1 more source
Mechanisms of SCN2A loss of function do not predict presence or phenotype of epilepsy
Epilepsia, EarlyView.Abstract Objective SCN2A loss‐of‐function (LoF) variants are associated with epilepsy (onset age ≥ 3 months), intellectual disability (ID), and autism spectrum disorder (ASD). Despite numerous identified variants and the description of phenotypic subgroups, relationships between Nav1.2 channel dysfunction and clinical phenotypes remain unclear.
Marsha Tan +23 more
wiley +1 more source
Recension: Annica Engström & Elisabeth Punzi (red.) Mad Studies, kulturarv & konst
Kulturella Perspektiv, 2023 Anna Nygren
doaj +1 more source
Ketogenic diet for infantile epileptic spasms
Epilepsia Open, EarlyView.Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury +3 more
wiley +1 more source
The Arrhythmogenic Spectrum of Mitral Valve Disease: Pathophysiology, Risk Stratification, and Surgical Management. [PDF]
J Clin MedPiscione M +7 more
europepmc +1 more source
European Eating Disorders Review, EarlyView.ABSTRACT Objective Our aim was to evaluate the diagnostic accuracy of the Eating Disorder Examination Questionnaire (EDE‐Q) scores and establish general and context‐specific cut‐off points for anorexia nervosa (AN) in Australian women. Methods The sample included 67 women with AN, 41 women with a history of AN and restored weight, 100 women with self ...
Rafael Moreton Alves da Rocha +3 more
wiley +1 more source