Results 91 to 100 of about 103,880,110 (253)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Negative valuation of undesirable outputs in evaluating the efficiency of production systems
MATEC Web of Conferences, 2017 This paper extends a data envelopment analysis (DEA) model that considers only desirable outputs in measuring efficiencies to incorporate undesirable outputs by requiring the associated multipliers to be negative.
Kao Chiang
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Experimental Study of the Freezing Point of γ-AlO/Water Nanofluid
Advances in Mechanical Engineering, 2012 Nanofluids are colloidal suspensions made of nanometer-sized particles dispersed in a conventional fluid. Their unusual thermal properties explain intensive investigations for several thermal and industrial applications.
Thierry Maré +4 more
doaj +1 more source
Made-to measure galaxy models - I Methodology [PDF]
, 2010 We rederive the made-to-measure (M2M) method of Syer & Tremaine for modelling stellar systems and individual galaxies, and demonstrate how extensions to the M2M method may be implemented and used.
Long, R. J., Mao, S.
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Jobs-to-be-Done in Made-to-Measure Tailoring
, 2018 This thesis examines specific jobs the customers of Janek ' a tailoring company - are trying to get done when obtaining made-to-measure garments. The goal of this thesis is to analyze the made-to-measure tailoring service through the lens of jobs-to-be-
Blatny, Matej
core +1 more source
Letter from the Dean, College of Humanities and Social Sciences
, 2021 CHSS Dean\u27s letter introducing Volume 5 of The Measure: A Journal of Undergraduate ...
Li, Chien-pin
core +1 more source