Results 21 to 30 of about 325,264 (256)
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
El Futuro del Pasado, 2020 Pese a la riqueza que evidencia en sus análisis locales, la producción historiográfica sobre el Sexenio Democrático presenta vacíos significativos en lo que respecta a la evolución de Madrid.
Santiago De Miguel Salanova
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Mariano Garrigues en Fortuny 14: la casa entre palacios
Veredes, Arquitectura y Divulgación, 2020 En el límite entre el ensanche norte de Madrid y el paseo de la Castellana coexistían, en una misma manzana, tres fincas palaciegas que fueron objeto de varias intervenciones en el tiempo, en la conversión de la Castellana a escenario de poder.
Ismael Amarouch García
doaj
La enseñanza secundaria en Madrid: estudio bibliográfico
Arbor: Ciencia, Pensamiento y Cultura, 2011 En este trabajo se analiza la historiografía sobre la educación secundaria en la Comunidad de Madrid. El análisis se refiere a la época contemporánea (siglos XIX y XX) y se tiene especialmente en cuenta las obras de historiografía publicadas en las ...
Miryam Carreño Rivero +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Madrid en los años treinta. Ambiente social, político, cultural y religioso / Madrid in the 1930´s. Social, political, cultural and religious situation [PDF]
Studia et Documenta, 2009 The city of Madrid of the 1930’s which witnessed the first steps of Opus Dei was the backdrop for great change. Firstly from the political point of view: the Monarchy had been replaced by the Republic; also the city itself was converted into an urban ...
Julio Montero, Javier Cervera Gil
doaj +1 more source
Las Semanas de Estudio de 1940: bases de la formación en el espíritu del Opus Dei de la posguerra española / The Study Weeks of 1940: The Foundations of the Formation in the Spirit of Opus Dei in the Spanish Post-War Period [PDF]
Studia et Documenta, 2020 This article seeks to identify the key ideas of the formation received by the members of Opus Dei who survived the Spanish Civil War and who brought about the great expansion that followed throughout the country.
Santiago Casas Rabasa
doaj +1 more source
Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons +33 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source