Results 31 to 40 of about 311,512 (255)
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
La construcción de la ciudad liberal: Madrid, 1859 y las propuestas de nuevos barrios
The analysis of the four proposals presented to Isabel II by Giraud Daguillon allow for comprehension of the contradictions inherent in the construction of the city in 19th-century Madrid.
Carlos Sambricio
doaj
This paper shows some of the conclusions about the image and the representation of the Feminine Socialist Group of Madrid, which are part of a larger research project concerning the feminine collective actions in Madrid between 1909-1931. First, it gives
Marta del Moral Vargas
doaj +1 more source
Astrocyte heterogeneity in brain metastases
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
The estate of La Zarzuela. New primary sources in its history
Contribution of primary sources for the history of the Royal Site of La Zarzuela from the end of 15th century until 1625, when this agricultural estate was bought by Cardenal Infante Fernando de Austria and then used by his brother, king Felipe IV, as a ...
Mª Ángeles Toajas Roger
doaj
Resumen Los procesos de gentrificación han ido evolucionando y mutando sus características. Madrid, en tanto que una ciudad de rango global está expuesta a estos cambios, uno de cuyos principales peligros reside en su detección temprana para la adopción
Álvaro Ardura Urquiaga
doaj +1 more source
Spatial biology in cancer epigenetics
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
La ciudad y la arquitectura en la pintura joven de los años 80’ en Madrid (1976-1992)
The so-called Spanish painting of the 80’ meant an interesting color revolution against conceptual art and the last echoes of informality. A new type of painting emerged in which the color, the historicism, and certain private topics caused an ...
Javier Torras de Ugarte
doaj
Se da cuenta de un nuevo tablero del corte estratigráfico del yacimiento paleolítico de San Isidro realizado por Emilio Rotondo. Conserva la única descripción detallada de su estratigrafía, lo que contribuye a mejorar la información de este histórico ...
Eugenio Sanz Pérez +1 more
doaj +1 more source
Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons +33 more
wiley +1 more source

