Results 121 to 130 of about 6,788,838 (210)

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3513-3526, October 2026.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Environmental Drivers of Metabolic Plasticity in Rubia cordifolia From the Western Himalaya: Implications for Phytochemical Diversity and Antioxidant Potential

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Environmental heterogeneity drives remarkable metabolic plasticity in Rubia cordifolia with significant variation in nutritional constituents, phytochemicals, bioactive compounds, and antioxidant activity among natural populations. High‐altitude populations exhibited higher accumulation of phenolics, flavonoids, alizarin, mollugin, and antioxidant ...
Deepti Tiwari, Sandeep Rawat, Veena Pandey, Vinod C. Joshi, Indra D. Bhatt, R. C. Sundriyal   +5 more
wiley   +1 more source

Molecular study of SRF-cofactor interactions. [PDF]

, 2008
Serum Response Factor regulates a large array of genes involved in diverse processes including cell proliferation, muscle differentiation and development, and cytoskeletal processes such as cell migration and adhesion.
Zaromytidou, A-I.
core  

Genome-Wide Analysis of the MADS-Box Transcription Factor Family in Solanum lycopersicum

, 2019
MADS-box family genes encode transcription factors that are involved in multiple developmental processes in plants, especially in floral organ specification, fruit development, and ripening.
Jianling Zhang, Xuhu Guo, Zongli Hu, Shibing Tian, Yunshu Wang, Guoping Chen   +5 more
core   +1 more source

USP25 stabilises GLI1 through K48‐linked deubiquitination within a reciprocal regulatory circuit in osteoarthritis models

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
GLI1‐centred USP25‐GLI1 reciprocal regulation in OA‐relevant models. Hedgehog/GLI1 signalling transcriptionally reinforces USP25 expression, while USP25 deubiquitinates and stabilises GLI1. This reciprocal circuit is associated with inflammatory and cartilage‐catabolic changes in the tested models.
Qian Zhang, Yinyan Ye, Yijie Huang, Jun Li, Dongfeng Huang   +4 more
wiley   +1 more source

Predicted miRNAs targeting MADS-box gene family in T. dicoccoides.

Predicted miRNAs targeting MADS-box gene family in T. dicoccoides.
Ghader Mirzaghaderi (3091797)
core   +1 more source

Function and Diversification of MADS-Box Genes in Rice

The Scientific World Journal, 2006
MADS-box genes play critical roles in a number of developmental processes in flowering plants, such as specification of floral organ identity, control of flowering time, and regulation of fruit development.
Takahiro Yamaguchi, Hiro-Yuki Hirano
doaj   +1 more source

DNA metabarcoding reveals key floral resources for native pollinators in post‐fire landscapes

Ecological Applications, Volume 36, Issue 7, October 2026.
Abstract Wildfires are a natural disturbance in dry ponderosa pine forest ecosystems, and are increasing in frequency and severity across western North America. The effects of wildfire on biotic and abiotic conditions have important implications for higher trophic levels, including native bees. We sought to quantify the responses of flowering plants to
Autumn Maust, Ellen M. Reese, Madeleine Strait, Patrick C. Tobin   +3 more
wiley   +1 more source

AhMADS6‐Mediated Repression of AhHD‐Zip Contributes to Growth Habit Regulation in Cultivated Peanut (Arachis hypogaea L.)

Plant Biotechnology Journal, EarlyView.
Yuanjin Fang, Lei Shi, Boyang Zhang, Han Liu, Xiaobo Wang, Pengyu Qu, Huanhuan Zhao, Lulu Xue, Xiaona Li, Feiyan Qi, Ziqi Sun, Zheng Zheng, Xiaodong Dai, Wenzhao Dong, Bingyan Huang, Xinyou Zhang   +15 more
wiley   +1 more source

First Observation of Wild Double‐Flowered Rhododendron nivale With Stamen Petaloidy and Possible Parallel Evolution

Ecology and Evolution, Volume 16, Issue 10, October 2026.
We report the first discovery of wild double‐flowered populations of the alpine dwarf shrub Rhododendron nivale on the eastern Qinghai‐Tibet Plateau. Two geographically isolated populations (> 800 km apart) show nearly identical stamen petaloidy and floral modifications in similar harsh high‐altitude habitats, suggesting possible parallel evolution ...
Xuyan Chen, Shuxing Deng, Zhaoshan Wang
wiley   +1 more source