Results 51 to 60 of about 9,900 (188)

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Characterization analyses of MADS-box genes highlighting their functions with seed development in Ricinus communis

Frontiers in Plant Science
The MADS-box gene family plays a pivotal role in regulating floral organ development and various aspects of plant growth. Despite its well-established importance in many species, the function and evolution of MADS-box genes in Ricinus communis (castor ...
Jing Sun, Zekun Zhou, Fanqing Meng, Mengyun Wen, Aizhong Liu, Anmin Yu, Anmin Yu, Anmin Yu   +7 more
doaj   +1 more source

Enabling the study of gene function in gymnosperms: Virus‐induced gene silencing in Ephedra tweedieana

Applications in Plant Sciences, EarlyView.
Abstract Premise As the sister clade to angiosperms, extant gymnosperms are crucial for reconstructing ancestral gene regulatory networks in seed plants. This highlights the need for model systems representing each of their distinct lineages. However, tools to quickly and effectively investigate gene function in gymnosperms are still limited due to the
Anthony G. K. Garcia, Jo Trang Bùi, Todd P. Michael, Stefanie M. Ickert‐Bond, Verónica S. Di Stilio   +4 more
wiley   +1 more source

Genome-wide identification of a MADS-box transcription factor family and their expression during floral development in Coptis teeta wall

BMC Plant Biology
Background MADS-box transcription factors have been shown to be involved in multiple developmental processes, including the regulation of floral organ formation and pollen maturation. However, the role of the MADS-box gene family in floral development of
Shao-Feng Duan, Ji-Chen Yu, Timothy Charles Baldwin, Yuan Yuan, Gui-Sheng Xiang, Rui Cui, Yan Zhao, Xin-Chun Mo, Ying-Chun Lu, Yan-Li Liang   +9 more
doaj   +1 more source

Genome-wide identification, characterization of the MADS-box gene family in Chinese jujube and their involvement in flower development

Scientific Reports, 2017
MADS-box genes encode transcription factors that are involved in plant development control (particularly in floral organogenesis) and signal transduction pathways, though a comprehensive analysis of MADS-box family proteins in Chinese jujube (Ziziphus ...
Liman Zhang, Jin Zhao, Chunfang Feng, Mengjun Liu, Jiurui Wang, Yafei Hu   +5 more
doaj   +1 more source

Genome-Wide Analysis of MADS-Box Genes in Foxtail Millet (Setaria italica L.) and Functional Assessment of the Role of SiMADS51 in the Drought Stress Response

Frontiers in Plant Science, 2021
MADS-box transcription factors play vital roles in multiple biological processes in plants. At present, a comprehensive investigation into the genome-wide identification and classification of MADS-box genes in foxtail millet (Setaria italica L.) has not ...
Wan Zhao, Wan Zhao, Li-Li Zhang, Zhao-Shi Xu, Liang Fu, Hong-Xi Pang, You-Zhi Ma, Dong-Hong Min   +7 more
doaj   +1 more source

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Impact of Agitation Power Input on Aspergillus oryzae Metabolism: Application of Multi‐Omics on an Industrial Enzyme Fermentation

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The agitation power input substantially impacts the oxygen transfer rate in aerobic fermentation processes. Furthermore, in a carbon‐limited process where the substrate feed rate is controlled by the concentration of dissolved oxygen, the power input will consequently govern the feed rate.
Mariana Albino, Jean‐Marie Mouillon, Gisela Nadal‐Rey, Carina L. Gargalo, Ulrich Krühne, Krist V. Gernaey, Mads O. Albæk   +6 more
wiley   +1 more source

Unpacking early risks for peer victimization: A network analysis of early temperament and polygenic risk scores

JCPP Advances, EarlyView.
Abstract Background Children who show difficult temperament are at risk of peer victimisation, which in turn associates with numerous negative outcomes later in life. We used network analysis to examine whether specific aspects of difficult temperament contributed to these associations, and whether the links were moderated by variations in genetic ...
Tom C.‐H. Wu, Deniz Konac, Liliana Garcia‐Mondragon, Alex F. Martin, Barbara Maughan, Ted Barker   +5 more
wiley   +1 more source

Genome-wide identification of the MADS-box transcription factor family in pear (Pyrus bretschneideri) reveals evolution and functional divergence [PDF]

PeerJ, 2017
MADS-box transcription factors play significant roles in plant developmental processes such as floral organ conformation, flowering time, and fruit development.
Runze Wang, Meiling Ming, Jiaming Li, Dongqing Shi, Xin Qiao, Leiting Li, Shaoling Zhang, Jun Wu   +7 more
doaj   +2 more sources