Results 21 to 30 of about 1,314 (148)

Kinome analysis of Madurella mycetomatis identified kinases in the cell wall integrity pathway as novel potential therapeutic drug targets in eumycetoma caused by Madurella mycetomatis. [PDF]

PLoS Neglected Tropical Diseases
Eumycetoma is a neglected tropical subcutaneous disease most commonly caused by the fungus Madurella mycetomatis. Currently, eumycetoma is treated by a combination of antifungal therapy and surgery, with limited success rates.
Mickey Konings, Nikolaos Strepis, Ri-Ichiroh Manabe, Akira Hasegawa, Somdatta Chaudhari, Saskia du Pré, Marij Schippers, Michihira Tagami, Jingyi Ma, Yasushi Okazaki, Matthew Todd, Bernhard Biersack, Vijay Masand, Annelies Verbon, Takeya Kasukawa, Imad Abugessaisa, Wendy W J van de Sande   +16 more
doaj   +2 more sources

Madurella mycetomatis-Induced Massive Shoulder Joint Destruction: A Management Challenge. [PDF]

PLoS Neglected Tropical Diseases, 2016
Peter S Scolding, Mustafa A Q Abbas, Roa Fathelrahman Omer, Ahmed Hassan Fahal   +3 more
doaj   +5 more sources

Madurella mycetomatis, the main causative agent of eumycetoma, is highly susceptible to olorofim. [PDF]

J Antimicrob Chemother, 2020
OBJECTIVES: Eumycetoma is currently treated with a combination of itraconazole therapy and surgery, with limited success. Recently, olorofim, the lead candidate of the orotomides, a novel class of antifungal agents, entered a Phase II trial for the ...
Lim W, Eadie K, Konings M, Rijnders B, Fahal AH, Oliver JD, Birch M, Verbon A, van de Sande W.   +8 more
europepmc   +3 more sources

Th-1, Th-2 Cytokines Profile among Madurella mycetomatis Eumycetoma Patients. [PDF]

PLoS Neglected Tropical Diseases, 2016
Eumycetoma is a progressive and destructive chronic granulomatous subcutaneous inflammatory disease caused by certain fungi, the most common being Madurella mycetomatis.
Amre Nasr, Amir Abushouk, Anhar Hamza, Emmanuel Siddig, Ahmed H Fahal   +4 more
doaj   +4 more sources

Madurella mycetomatis infection following allogenic stem cell transplantation for aplastic anemia

Mediterranean Journal of Hematology and Infectious Diseases, 2012
Madurella mycetomatis is the most common fungal agent causing eumycetoma. The commonest clinical presentation of the infection is the appearance of multiple sinuses with discharge of grains, which are the colonies of the fungus.
Sanjeev Kumar Sharma, Anjan Mukherjee, Avinash Kumar Singh, Tuika Seth, Suman Kumar, Pravas Mishra, Immaculata Xess, Somesh Gupta, Manoranjan Mahapatra, Haraprasad Pati   +9 more
doaj   +4 more sources

Environmental detection of eumycetoma pathogens using multiplex real-time PCR for soil DNA in Sennar State, Sudan [PDF]

Tropical Medicine and Health, 2023
Background Mycetoma is a chronic disease affecting the skin and subcutaneous tissue endemic in the tropical and subtropical regions. Several bacteria and fungi can cause mycetoma, but fungal mycetoma (eumycetoma) is challenging because the treatment ...
Hiroki Hashizume, Suguru Taga, Masayuki K. Sakata, Mahmoud Hussein, Emmanuel Edwar Siddig, Toshifumi Minamoto, Ahmed Hassan Fahal, Satoshi Kaneko   +7 more
doaj   +4 more sources

Identification of Microbial-Based Natural Products as Potential CYP51 Inhibitors for Eumycetoma Treatment: Insights from Molecular Docking, MM-GBSA Calculations, ADMET Analysis, and Molecular Dynamics Simulations [PDF]

Pharmaceuticals
Background/Objectives: Eumycetoma, caused by Madurella mycetomatis, is a chronic fungal infection with limited treatment options and increasing drug resistance.
Tilal Elsaman, Mohamed Khalid Alhaj Awadalla, Malik Suliman Mohamed, Eyman Mohamed Eltayib, Magdi Awadalla Mohamed   +4 more
doaj   +2 more sources

Eumycetoma by Madurella mycetomatis with 30 years of evolution: therapeutic challenge [PDF]

Anais Brasileiros de Dermatologia, 2013
We report a case of eumycetoma by Madurella mycetomatis on the buttocks and thighs in an adult immunocompetent patient, diagnosed after 30 years of clinical development.
Felipe Maurício Soeiro Sampaio, Maria Clara Gutierrez Galhardo, Leonardo Pereira Quintella, Paulo Roberto Cotrim de Souza, Janice Mary Chicarino de Oliveira Coelho, Antonio Carlos Francesconi do Valle   +5 more
doaj   +5 more sources

Sandalwood Sesquiterpene (Z)-α-Santalol Exhibits In Vivo Efficacy Against Madurella mycetomatis in Galleria mellonella Larvae [PDF]

Molecules
In continuation of our recent report on the in vitro activity of sandalwood essential oils and their major components, the sesquiterpenes (Z)-α- and -β-santalols, against the pathogenic fungus Madurella mycetomatis, causative agent of the neglected ...
Shereen O. Abd Algaffar, Stephan Seegers, Shaoqin Zhou, Prabodh Satyal, William N. Setzer, Thomas J. Schmidt, Sami A. Khalid   +6 more
doaj   +2 more sources

Madurella mycetomatis infection of the buttock in an Eritrean refugee in Switzerland: a case report [PDF]

Journal of Medical Case Reports, 2019
Background Mycetoma is a neglected infectious disease caused by a fungus (eumycetoma) or bacteria (actinomycetoma); it is characterized by chronic local inflammation with sinus formation and purulent discharge. Its course can be quite devastating because
Carine Mekoguem, Cécile Triboulet, Alexandre Gouveia   +2 more
doaj   +2 more sources