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Eumycetoma: pathogenesis, current treatments, and the search for new drugs [PDF]

Applied Microbiology and Biotechnology
Eumycetoma is a neglected tropical disease which can be caused by 69 different fungal species. In 2024, eumycetoma was listed as a high priority fungal infection on the fungal priority list of the World Health Organization. Eumycetoma is characterized by
Dounia El Yachioui, Tim Baltussen, Wendy W. J. van de Sande   +2 more
doaj   +4 more sources

Association of eumycetoma and schistosomiasis. [PDF]

PLoS Neglected Tropical Diseases, 2013
Eumycetoma is a morbid chronic granulomatous subcutaneous fungal disease. Despite high environmental exposure to this fungus in certain regions of the world, only few develop eumycetoma for yet unknown reasons.
Jaap J van Hellemond, Alieke G Vonk, Corné de Vogel, Rob Koelewijn, Norbert Vaessen, Ahmed H Fahal, Alex van Belkum, Wendy W J van de Sande   +7 more
doaj   +42 more sources

Eumycetoma of the Foot in a 70‐Year‐Old Male Farmer [PDF]

Clinical Case Reports
Clinicians should consider eumycetoma, actinomycotic mycetoma, and skin cancers in patients from tropical or subtropical regions who present with painless swelling and discharging sinuses.
Allahdad Khan, Saad Masood, Aseel Kamal
doaj   +4 more sources

An update on the development of novel antifungal agents for eumycetoma

Frontiers in Pharmacology, 2023
Eumycetoma, a chronic subcutaneous mycosis, responds poorly to the available antifungal treatments and patients often require extensive surgical resection or amputation of the affected limb. More effective treatments are needed for eumycetoma.
David J. Chandler, David J. Chandler, Alexandro Bonifaz, Wendy W. J. van de Sande   +3 more
doaj   +4 more sources

Encapsulated eumycetoma caused by Biatriospora mackinnonii

Medical Mycology Case Reports, 2022
Eumycetoma is a chronic infection due to filamentous fungi. Herein, we report a case of eumycetoma presenting as a subcutaneous encapsulated lesion on the right leg with no previous traumatic implantation.
Daniela Arteaga, Andrés Tirado-Sánchez, Denisse Vázquez-González, Luis-Miguel Moreno, Wendy van de Sande, Alexandro Bonifaz   +5 more
doaj   +5 more sources

The First Case of Fusarium falciforme Eumycetoma in Sudan and an Extensive Literature Review about Treatment Worldwide [PDF]

Journal of Fungi, 2023
Eumycetoma is an infectious disease caused by various fungal pathogens. The disease is characterised by black and pale-yellowish grain discharge. In this communication, we report a case of eumycetoma with a pale grain foot-eumycetoma caused by Fusarium ...
Emmanuel Edwar Siddig, Ayman Ahmed, Hala Fathi Eltigani, Sahar Mubarak Bakhiet, Wendy W. J. van de Sande, Ahmed Hassan Fahal   +5 more
doaj   +5 more sources

Identification of Microbial-Based Natural Products as Potential CYP51 Inhibitors for Eumycetoma Treatment: Insights from Molecular Docking, MM-GBSA Calculations, ADMET Analysis, and Molecular Dynamics Simulations [PDF]

Pharmaceuticals
Background/Objectives: Eumycetoma, caused by Madurella mycetomatis, is a chronic fungal infection with limited treatment options and increasing drug resistance.
Tilal Elsaman, Mohamed Khalid Alhaj Awadalla, Malik Suliman Mohamed, Eyman Mohamed Eltayib, Magdi Awadalla Mohamed   +4 more
doaj   +3 more sources

Repurposing FDA-Approved Drugs for Eumycetoma Treatment: Homology Modeling and Computational Screening of CYP51 Inhibitors. [PDF]

Int J Mol Sci
Eumycetoma, a chronic fungal infection caused by Madurella mycetomatis, is a neglected tropical disease characterized by tumor-like growths that can lead to permanent disability and deformities if untreated.
Mohamed MA, Awadalla MKA, Mohamed MS, Elsaman T, Eltayib EM.   +4 more
europepmc   +3 more sources

Eumycetoma on the Back. [PDF]

Am J Trop Med Hyg
A healthy 35-year-old man from Mauritania presented to the dermatology department with a several-year history of evolving lesions on his back (Figure 1).
Ball M, Smith DJ.
europepmc   +4 more sources

<i>Madurella tropicana</i> and <i>Madurella pseudomycetomatis</i> identified as new causative agents of black grain eumycetoma in Senegal. [PDF]

Med Mycol Case Rep
This study reports Madurella tropicana and Madurella pseudomycetomatis as pathogens causing eumycetoma in Senegal. The dominant species, Madurella mycetomatis, shares morphological features with both.
Faye M, Ndiaye M, Gaye AM, Konings M, Van de Sande W, Sow D.   +5 more
europepmc   +5 more sources