Results 31 to 40 of about 1,314 (148)

Epitope-Based Peptide Vaccine Against Fructose-Bisphosphate Aldolase of Using Immunoinformatics Approaches [PDF]

Bioinformatics and Biology Insights, 2018
Background: Mycetoma is a distinct body tissue destructive and neglected tropical disease. It is endemic in many tropical and subtropical countries.
Arwa A Mohammed, Ayman MH ALnaby, Solima M Sabeel, Fagr M AbdElmarouf, Amina I Dirar, Mostafa M Ali, Mustafa A Khandgawi, Abdelhameed M Yousif, Eman M Abdulgadir, Magdi A Sabahalkhair, Ayman E Abbas, Mohammed A Hassan   +11 more
doaj   +2 more sources

Sandalwood Oils of Different Origins Are Active In Vitro against Madurella mycetomatis, the Major Fungal Pathogen Responsible for Eumycetoma [PDF]

Molecules
In the search for new bioactive agents against the infectious pathogen responsible for the neglected tropical disease (NTD) mycetoma, we tested a collection of 27 essential oils (EOs) in vitro against Madurella mycetomatis, the primary pathogen ...
Shereen O. Abd Algaffar, Stephan Seegers, Prabodh Satyal, William N. Setzer, Thomas J. Schmidt, Sami A. Khalid   +5 more
doaj   +2 more sources

Novel Compound MMV1804559 from the Global Health Priority Box Exhibits In Vitro and In Vivo Activity against Madurella mycetomatis. [PDF]

Int J Mol Sci
Objectives: Eumycetoma is a neglected tropical disease (NTD) characterized by subcutaneous lesions and the formation of grains. Attempts to treat eumycetoma involve a combination of antifungal treatment and surgery, although the outcome is frequently ...
Ma J, Eadie K, Schippers M, Fahal A, Laleu B, Verbon A, van de Sande WWJ.   +6 more
europepmc   +3 more sources

A drug-repurposing screen of FDA- and EMA-approved drugs identifies two NF-κB inhibitors active against eumycetoma. [PDF]

J Antimicrob Chemother
BackgroundMycetoma caused by Madurella mycetomatis (eumycetoma) is a neglected tropical disease that forms tumorous lesions in the subcutaneous tissue. The current standard treatment for eumycetoma consists of antifungal treatment combined with surgery ...
Ma J, van Doodewaerd BR, Biersack B, Verbon A, Geurink PP, van de Sande WWJ.   +5 more
europepmc   +3 more sources

Madurella mycetomatis grains within a eumycetoma lesion are clonal. [PDF]

Med Mycol, 2022
Abstract Eumycetoma is a neglected tropical infection of the subcutaneous tissue, characterized by tumor-like lesions and most commonly caused by the fungus Madurella mycetomatis. In the tissue, M. mycetomatis organizes itself in grains, and within a single lesion, thousands of grains can be present.
Nyuykonge B, Siddig EE, Konings M, Bakhiet S, Bakhiet S, Verbon A, Klaassen CHW, Fahal AH, van de Sande WWJ.   +8 more
europepmc   +4 more sources

Epidemiological cut-off values for itraconazole and ravuconazole for Madurella mycetomatis, the most common causative agent of mycetoma. [PDF]

Mycoses, 2022
Abstract Background Eumycetoma is a neglected tropical disease. It is a chronic inflammatory subcutaneous infection characterised by painless swellings which produce grains. It is currently treated with a combination of itraconazole and surgery. In an ongoing clinical study, the efficacy of fosravuconazole, the prodrug of ravuconazole, is being ...
Nyuykonge B, Siddig EE, Mhmoud NA, Nyaoke BA, Zijlstra EE, Verbon A, Bakhiet S, Bakhiet S, Fahal AH, van de Sande WWJ.   +9 more
europepmc   +2 more sources

The contribution of mycetoma grains to suboptimal disease management [PDF]

Nature Communications
A defining feature of mycetoma is the presence of grains, which are dense, compact structures composed of the causative bacterial or fungal microorganisms.
Ahmed Hassan Fahal, Abdalla Osaman Ahmed, Lamyaa El Hassan, Ali Awadallah Saeed   +3 more
doaj   +2 more sources

The Mycetoma Knowledge Gap: Identification of Research Priorities [PDF]

, 2014
Mycetoma is a tropical disease which is caused by a taxonomically diverse range of actinomycetes (actinomycetoma) and fungi (eumycetoma). The disease was only recently listed by the World Health Organization (WHO) as a neglected tropical disease (NTD ...
Fahal, Ahmed Hassan, Goodfellow, Michael, Maghoub, El Sheikh, Van de Sande, Wendy W. J., Wanke, Bodo, Welsh Lozano, Oliverio, Zijlstra, Ed E.   +6 more
core   +27 more sources

Ibrexafungerp prolongs survival and reduces the eumycetoma grain size in Galleria mellonella infection models of two different causative agents of eumycetoma. [PDF]

J Antimicrob Chemother
OBJECTIVES: Eumycetoma is a neglected tropical fungal disease of the subcutaneous tissue that is currently not treatable with medication only. Standard itraconazole therapy is combined with surgical excision of the lesion.
Ma J, Eadie K, Konings M, Fahal A, Verbon A, van de Sande WWJ.   +5 more
europepmc   +4 more sources

The development of a multiplex recombinase polymerase amplification reaction to detect the most common causative agents of eumycetoma. [PDF]

Eur J Clin Microbiol Infect Dis
PURPOSE: Mycetoma is a neglected tropical disease that affects the subcutaneous tissue. The disease can be caused by over 90 different pathogens, including both bacteria (actinomycetoma) and fungi (eumycetoma).
Konings M, Siddig E, Eadie K, Minlekib CP, Faye M, Sow D, Fahal A, Verbon A, van de Sande W.   +8 more
europepmc   +4 more sources