Results 41 to 50 of about 1,314 (148)

S6.5b Genomics and metagenomics of Madurella mycetomatis

Medical Mycology, 2022
Abstract S6.5 Efforts of improving the management of mycetoma: working towards the 2030 goals, September 22, 2022, 4:45 PM - 6:15 PM     Mycetoma is a debilitating disease recognized as a neglected tropical disease by the World Health
Litvintseva, Anastasia, Bakhiet, Sahar, Gade, Lalitha, Bagal, Ujwal, Wagner, Darlene, Siddig, Emmanuel Edwar, Mhmoud, Najwa Adam, Fahal, Ahmed   +7 more
openaire   +4 more sources

A murine model ofMadurella mycetomatiseumycetoma [PDF]

FEMS Immunology & Medical Microbiology, 2003
Eumycetoma due to Madurella mycetomatis is a major mycological health problem in endemic areas. We infected BALB/c mice (male or female) with various amounts of M. mycetomatis mycelium, containing sterilized soil as a natural adjuvant or Freund's incomplete adjuvant. Mice differed with respect to age and immune status. Intraperitoneal, subcutaneous and
Ahmed, AOA (Abdalla), van Vianen, W (Wim), ten Kate, Marian, Laureijssen - van de Sande, Wendy, Belkum, Alex, Fahal, AH, Verbrugh, Henri, Woudenberg, Irma   +7 more
openaire   +2 more sources

The impact of AlphaFold Protein Structure Database on the fields of life sciences

PROTEOMICS, Volume 23, Issue 17, September 2023., 2023
Abstract Arguably, 2020 was the year of high‐accuracy protein structure predictions, with AlphaFold 2.0 achieving previously unseen accuracy in the Critical Assessment of Protein Structure Prediction (CASP). In 2021, DeepMind and EMBL‐EBI developed the AlphaFold Protein Structure Database to make an unprecedented number of reliable protein structure ...
Mihaly Varadi, Sameer Velankar
wiley   +1 more source

Evaluation of the Antiparasitic and Antifungal Activities of Synthetic Piperlongumine‐Type Cinnamide Derivatives: Booster Effect by Halogen Substituents

ChemMedChem, Volume 18, Issue 12, June 15, 2023., 2023
Halo‐ed ground: New piperlongumine‐type cinnamides with halogen substituents and the potential to bind tubulin show considerable activities against Toxoplasma gondii and Leishmania major protozoal parasites, and moderate activity against Trypanosoma brucei and Madurella mycetomatis, depending on the halogen atom present.
Tariq A. Khan, Ibrahim S. Al Nasr, Waleed S. Koko, Jingyi Ma, Simon Eckert, Lucas Brehm, Ridha Ben Said, Ismail Daoud, Riadh Hanachi, Seyfeddine Rahali, Wendy W. J. van de Sande, Klaus Ersfeld, Rainer Schobert, Bernhard Biersack   +13 more
wiley   +1 more source

Using a Madurella mycetomatis‐specific PCR on grains obtained via non‐invasive fine‐needle aspirated material is more accurate than cytology

Mycoses, Volume 66, Issue 6, Page 477-482, June 2023., 2023
Abstract Background Eumycetoma is a chronic subcutaneous inflammatory fungal infection most often caused by the fungus Madurella mycetomatis. Using a species‐specific PCR on DNA directly isolated from grains is currently the most reliable method for species identification.
Emmanuel Edwar Siddig, Ayman Ahmed, Omnia Babekir Hassan, Sahar Mubarak Bakhiet, Annelies Verbon, Ahmed Hassan Fahal, Wendy W. J. van de Sande   +6 more
wiley   +1 more source

Screening the pandemic response box identified benzimidazole carbamates, Olorofim and ravuconazole as promising drug candidates for the treatment of eumycetoma.

PLoS Neglected Tropical Diseases, 2022
Eumycetoma is a chronic subcutaneous neglected tropical disease that can be caused by more than 40 different fungal causative agents. The most common causative agents produce black grains and belong to the fungal orders Sordariales and Pleosporales.
Wilson Lim, Bertrand Nyuykonge, Kimberly Eadie, Mickey Konings, Juli Smeets, Ahmed Fahal, Alexandro Bonifaz, Matthew Todd, Benjamin Perry, Kirandeep Samby, Jeremy Burrows, Annelies Verbon, Wendy van de Sande   +12 more
doaj   +1 more source

Comparing the performance of the common used eumycetoma diagnostic tests

Mycoses, Volume 66, Issue 5, Page 420-429, May 2023., 2023
Abstract Objectives Mycetoma is a neglected tropical implantation disease caused by 70 different infectious agents. Identifying the causative organism to the species level is essential for appropriate patient management. Ultrasound, histopathology, culture and two species‐specific PCRs are most the commonly used methods for species identification in ...
Emmanuel Edwar Siddig, Bertrand Nyuykonge, Najwa Adam Mhmoud, Omnia Babekir Abdallah, Mustafa El Nour Bahar, Eiman Siddig Ahmed, Borna Nyaoke, Eduard E. Zijlstra, Annelies Verbon, Sahar Mubarak Bakhiet, Ahmed Hassan Fahal, Wendy W. J. van de Sande   +11 more
wiley   +1 more source

Wako β‐D‐glucan assay can be used to measure serum β‐D‐glucan in Sudanese patients to aid with diagnosis of eumycetoma caused by Madurella mycetomatis

Journal of the European Academy of Dermatology and Venereology, Volume 37, Issue 4, Page 783-786, April 2023., 2023
Abstract Background Eumycetoma is a neglected tropical infection of the subcutaneous tissue commonly caused by the fungus Madurella mycetomatis. Previously, we demonstrated that β‐D‐glucan was present in the serum of eumycetoma patients. Objective To compare the performance of the recently approved easy‐to‐use Wako β‐D‐glucan assay to that of the ...
Bertrand Nyuykonge, Emmanuel Siddig, Najwa A. Mhmoud, Sahar Bakhiet, Eduard Zijlstra, Annelies Verbon, Ahmed H. Fahal, Wendy W. J. van de Sande   +7 more
wiley   +1 more source

Diagnostics to support mycetoma management—Development of two target product profiles

Tropical Medicine &International Health, Volume 27, Issue 12, Page 1059-1064, December 2022., 2022
Abstract Objective Mycetoma is a neglected tropical disease caused by more than 70 different microorganisms and identified by the WHO as one of the high‐priority diseases for developing diagnostic tests. To ensure the production of diagnostic assays for use by clinical staff in endemic regions, target product profiles (TPPs) were designed.
Noah Fongwen, Kingsley B. Asiedu, Sahar Bakhiet, Alexandro Bonifaz, Israel Cruz, Daniel Argaw, Guadalupe Estrada‐Chavez, Ahmed H. Fahal, Ana Litvintseva, Michael Marks, Mario C. Salinas‐Carmona, Doudou Sow, Wendy W. J. van de Sande   +12 more
wiley   +1 more source

Ultrasound‐guided fine‐needle aspiration cytology significantly improved mycetoma diagnosis

Journal of the European Academy of Dermatology and Venereology, Volume 36, Issue 10, Page 1845-1850, October 2022., 2022
Abstract Background Ultrasound (US)‐guided fine‐needle aspiration cytology (US‐FNAC) has improved the diagnosis of many malignancies, infections and other diseases as it is safe, simple, quick and accurate. In mycetoma, it is assumed that this technique may have a better diagnostic yield than the conventional FNAC as it can accurately identify the ...
E.E. Siddig, O. El Had Bakhait, M. El nour Hussein Bahar, E. Siddig Ahmed, S.M. Bakhiet, M. Motasim Ali, O. Babekir Abdallah, R. Ahmed Hassan, A. Verbon, W.W.J. van de Sande, A.H. Fahal   +10 more
wiley   +1 more source