Results 51 to 60 of about 125 (121)
ABSTRACT Jasmonate (JA) regulates defence responses in plants. However, JA‐induced defence often results in growth inhibition. This process is largely mediated by MYC2, the master regulator of JA signalling. Nevertheless, the underlying molecular mechanisms have not yet been fully uncovered.
Luyan Zhao +3 more
wiley +1 more source
Il contributo prende in esame i disegni, mai studiati in precedenza con gli strumenti della storia dell’arte, che illustrano i manoscritti delle Historiae Ferrarienses, opera di Pellegrino Prisciani dedicata al duca Ercole I d’Este.
Sonia Cavicchioli
core
ABSTRACT This article contributes to the history of material culture and intellectual biography by definitively identifying the Paduan scholar Matteo Macigni (ca. 1510–1582) as the author of the annotations found in a 1535 copy of Albrecht Dürer’s Institutionum geometricarum currently preserved in Vicenza.
Laura Moretti
wiley +1 more source
Embracing complexity in transfusion research
Abstract Complexity science investigates how complex systems behave and how we interact with them. Its implementation in clinical transfusion research is limited, even though human cells, organ systems, bodies, hospitals and blood supply systems are all examples of complex systems.
S. F. Fustolo‐Gunnink
wiley +1 more source
Abstract Dual training is a subject of interest due to the current political initiatives in education to promote training programmes that bring the education system closer to both professional employment and the business fabric of a given region. Given the influence of educational and labour legislation on the scientific approach to dual education ...
Silvia Sierra‐Martínez +3 more
wiley +1 more source
SNPs in SH3RF3 decrease the age of onset of Alzheimer's disease (AD). Reduced SH3RF3 blunts human microglial JNK and NFkB signaling and downstream inflammatory cytokine production, which may partially explain how SH3RF3 SNPs protect against AD. ABSTRACT Understanding how high‐risk individuals are protected from Alzheimer's disease (AD) may illuminate ...
Ronak Patel +13 more
wiley +1 more source
Humanin Mitigates Aβ‐Induced Retinal Pigment Epithelium Injury via AMPK‐Beclin1‐Dependent Mitophagy
Humanin (HN) enhanced the clearance of Aβ‐accumulated mitochondria in the RPE while preserving retinal function and RPE barrier integrity. HN activated AMP‐activated protein kinase (AMPK), leading to phosphorylation of ULK1 and Beclin1, which promoted the interaction between Beclin1 and Parkin and their translocation to mitochondria.
Ha Young Jang +7 more
wiley +1 more source
circRMST (hsa_circ_0099634) is by far the most abundant isoform from the RMST locus. It is highly expressed in cancer cells throughout ependymoma patient samples and is located in the cytoplasm. circRMST knockdown causes cell cycle arrest and induces differentiation, and it is a marker for poor prognosis. The figure is made using BioRender.
Ulvi Ahmadov +6 more
wiley +1 more source
Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga +11 more
wiley +1 more source
ABSTRACT Grapevine powdery mildew, caused by the fungus Erysiphe necator, is one of the most prevalent obligate biotrophic pathogens in vineyards, posing a significant threat to grape production. Despite its impact, research on E. necator pathogenicity and grapevine responses remains limited.
Bo Mu +10 more
wiley +1 more source

