Results 41 to 50 of about 17,590,608 (258)

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

Oceanic Rossby waves drive inter-annual predictability of net primary production in the central tropical Pacific

Environmental Research Letters, 2022
In the Pacific Ocean, off-equatorial Rossby waves (RWs), initiated by atmosphere-ocean interaction, modulate the inter-annual variability of the thermocline.
Sebastian Brune, Maria Esther Caballero Espejo, David Marcolino Nielsen, Hongmei Li, Tatiana Ilyina, Johanna Baehr   +5 more
doaj   +1 more source

The Plant‐to‐Plant Circular Strategy: Coupling Photodegradation and Phytoremediation With Plant‐Based Nanomaterials for Plastic Degradation

Advanced Science, EarlyView.
Plant‐based nanomaterials derived from alfalfa serve as dual‐function catalysts, coupling photodegradation and phytoremediation to degrade polyethylene under UV‐A light and in soil. The nanomaterials work synergistically with alfalfa and soil microbes, achieving efficient plastic breakdown without trophic transfer.
Haoran Liu, Lena Ciric, Yuheng Wang, Ziru Pei, Manpreet Bhatti   +4 more
wiley   +1 more source

ENSO effects on hydropower and climate adaptation strategies in four Colombian case studies

Journal of Hydrology: Regional Studies
Study Region: This study explores three Colombian regions where hydroclimatic fluctuations create significant operational challenges for hydropower systems, particularly those associated with El Niño-Southern Oscillation (ENSO): the upper and middle ...
Laura Pulgarín-Morales, Tobias Krueger
doaj   +1 more source

Estimadores Bayesianos de distribuciones Weibull aplicados a un modelo de líneas de espera G/G/s || Bayesian estimators of Weibull distributions applied to a model of waiting lines G/G/s

Revista de Métodos Cuantitativos para la Economía y la Empresa, 2020
Se ha estudiado en la literatura la aproximación de los modelos G/G/s a partir de modelos markovianos M/M/s. Un estudio de un modelo de colas se presenta en el presente artículo usando tiempos de llegadas y servicios Weibull distribuidos cuya estimación ...
Vargas-Sánchez, Jhon Jairo, Causado, Edwin, Mercado, Hugo   +2 more
doaj   +1 more source

Inició la fase de prototipado del proyecto de innovación que beneficia a 30 empresas del Magdalena

, 2023
El proyecto Sistema de Gestión de Innovación, liderado por la Universidad del Magdalena en alianza con la Cámara de Comercio de Santa Marta para el Magdalena, inició su fase de prototipado con las 30 empresas beneficiadas. Durante varios días se llevaron
Peña Curieux, Digna
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TiO6 as a Compensatory Structural Unit in Co‐Free, High‐Ni Layered Oxide for Durable Lithium‐Ion Batteries

Advanced Science, EarlyView.
Ti substitution stabilizes Co‐free high‐Ni layered oxides through both structural and electronic effects. TiO6 octahedra act as compensatory structural units that help interrupt cooperative Jahn–Teller distortion and suppress detrimental phase transitions, while the electron‐withdrawing inductive effect of Ti stabilizes the oxygen lattice. As a result,
Bixian Ying, Zhenjie Teng, Jun Wang, Honghong Tian, Charlotte von Petersdorff‐Campen, Rommel T. Tolla, Iuliia Mikulska, Linus Voigt, Sascha Nowak, Verena Naber, Alexander Schökel, Yuanming Liu, Michael Merz, Peter Nagel, Stefan Schuppler, Katja Frenzel, Adrian Jonas, Lena Mathies, Martin Winter, Karin Kleiner   +19 more
wiley   +1 more source

Prospective Gas Resources with Emphasis on Wet Gas in Onshore Colombian Basins

Revista Facultad de Ingeniería, 2023
Colombia is a gas producing country, which has allowed it to maintain a high level of self-sufficiency for the past 40 years, including Natural Gas (NG) and liquefied petroleum gas (LPG) in activities primarily related to residential consumption ...
Claudia-Rosa Posada-Saldarriaga, César-Augusto Mora-Hernández, Gleubis-Belén Silveira-Moreno, Mauricio-Alberto Bermúdez-Cella   +3 more
doaj   +1 more source

Magdalena territorio de paz [PDF]

, 2019
El Magdalena es un territorio conocido por la importancia estratégica de sus ecosistemas y su riqueza cultual. La diversidad de su oferta ambiental, patrimonio cultural, centros históricos, sitios arqueológicos, sumados a la fuerza de su profundo ...
Ramírez, Clinton
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