Results 101 to 110 of about 112,453 (312)

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

open access: yesAdvanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini   +24 more
wiley   +1 more source

The sequence to hydrogenate coronene cations: A journey guided by magic numbers [PDF]

open access: gold, 2016
Stéphanie Cazaux   +8 more
openalex   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

open access: yesAdvanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong   +11 more
wiley   +1 more source

Magical Thinking

open access: yesClinical and Translational Gastroenterology, 2014
Boardman, Charles R, Sonnenberg, Amnon
openaire   +2 more sources

Origins of Graphite Resistivity: Decoupling Stacking Fault and Rotational Misorientation

open access: yesAdvanced Science, EarlyView.
Interfacial dislocations critically influence interlayer transport in van der Waals (vdW) materials, yet quantifying their individual contributions remains challenging. We measure graphite's c‐axis resistivity and develop a decoupling strategy, revealing a resistivity ratio of ∼4507:74:1 for rotational misorientations, stacking faults, and AB stacking,
Weipeng Chen   +6 more
wiley   +1 more source

Leveraging Reaction Heterogeneity in Bimodal Cathodes to Enhance Longevity of SiO/Graphite | NCM Full cells

open access: yesAdvanced Science, EarlyView.
A bimodal cathode composed of single‐ and polycrystalline NCM particles induces end‐of‐discharge overpotential rise via reaction heterogeneity, effectively regulating the depth of discharge of SiO in SiO/graphite anodes. This design suppresses mechanical degradation of SiO and enables long‐term cycling stability without compromising the energy density ...
Hyoyeong Kim   +10 more
wiley   +1 more source

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