Results 111 to 120 of about 811,172 (335)
Advanced Science, EarlyView.This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik +13 more
wiley +1 more source
Review of: "Fishing Rods for Magic: Theatre Forum Tools to Support Primary School Students’ Active Engagement in Computer-Supported Collaborative Storytelling" [PDF]
, 2023 Stacy Delacruz
openalex +1 more source
Advanced Science, EarlyView.An enhanced sampling method is developed for molecular dynamics based on trained machine learning force fields to guide the construction of PANoptosis‐inhibiting carbonized polymer dots (Lu‐CDs) derived from a flavonoid compound for treating chemodrug‐induced nephrotoxicity.
Xinchen Liu +8 more
wiley +1 more source
Impacts of COVID-19 pandemic on early life gut microbiome
Gut MicrobesIncreased hygiene and sanitation are theorized to predispose to developing atopic diseases, a process potentially mediated by the gut microbiome. We hypothesized that the gut microbiome maturation has been altered by COVID-19 lockdown measures during the
Lin Zhang +24 more
doaj +1 more source
Advanced Science, EarlyView.Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao +36 more
wiley +1 more source
A Dynamic Gate Enables Regioselective Hydroxylation of Free Arginine by a Non‐Canonical Heme Enzyme
Advanced Science, EarlyView.The YqcI/YcgG enzyme AglA employs a unique “sandwich” fold and a dynamic gating mechanism to selectively hydroxylate AMPn‐Arg at Nε. Site‐directed mutations reprogram regioselectivity or enable activity on free arginine by altering hydrogen‐bond networks, precisely positioning substrates.
Yuan Sun +12 more
wiley +1 more source
Advanced Science, EarlyView.scPER presents an adversarial‐autoencoder framework that deconvolves bulk total RNA‐seq to quantify tumor‐microenvironment cell types and uncover phenotype‐linked subclusters. Across diverse benchmarks, scPER improves accuracy over existing tools.
Bingrui Li, Xiaobo Zhou, Raghu Kalluri
wiley +1 more source
Paradoxical Topological Soliton Lattice in Anisotropic Frustrated Chiral Magnets
Advanced Science, EarlyView.The article describes the discovery of a stable skyrmion‐antiskyrmion lattice (S‐AL) in anisotropic frustrated chiral magnets. This lattice has a net‐zero topological charge due to a balanced population of skyrmions and antiskyrmions. This is a paradoxical finding since these particles normally annihilate each other.
Sayan Banik +2 more
wiley +1 more source