Results 261 to 270 of about 808,060 (334)

Allosteric Inhibitors of SARS‐CoV‐2 RNA‐Dependent RNA Polymerase Based on N,N′‐Diphenylurea

ChemMedChem, EarlyView.
Inhibitors of SARS‐CoV‐2 RdRp activity based on N,N′‐diphenylurea scaffold have been identified. Several compounds exhibit residual activity (RA) below 50% in an enzymatic assay (at 10 µM concentration) and improved aqueous solubility compared to the previously reported series of inhibitors.
Artem Chayka, Matěj Danda, Alžběta Dostálková, Vojtěch Spiwok, Lamija Zijadic, Anna Klimešová, Marina Kapisheva, Michala Zgarbová, Jan Weber, Tomáš Ruml, Michaela Rumlová, Zlatko Janeba   +11 more
wiley   +1 more source

Is There More to Magic Mushrooms than Psilocybin? [PDF]

ACS Cent Sci
Johnson-Groh M.
europepmc   +1 more source

Investigating the Ligand‐Binding Properties of N‐arylbenzimidazoles as Novel Elastase Inhibitors

ChemMedChem, EarlyView.
A series of novel N‐[(3,5‐dimethylphenyl)methyl]‐1H‐benzimidazole derivatives is designed, synthesized, and evaluated for inhibitory activity against elastase. Several compounds demonstrate an antielastase activity, including the N‐(2‐bromophenyl)‐2‐(6‐chloro‐1‐(3,5‐dimethylbenzyl)‐1H‐benzo[d]imidazol‐2‐ylthio)acetamide, showing the greatest potency ...
Giovanna Pitasi, Sonia Floris, Francesca Mancuso, Giulia Savoca, Rosaria Gitto, Antonella Fais, Laura De Luca   +6 more
wiley   +1 more source

From international guidelines to practice: a multimethod evaluation of <i>BMJ</i> Rapid Recommendations focusing on suitability for adaptation and implementation. [PDF]

BMJ Open
Seterelv SS, Gupta S, Kouri A, Florez ID, Agoritsas T, Vandvik PO, Van de Velde S.   +6 more
europepmc   +1 more source

The magic of elliptical orbits.

, 1974
M. Berrondo, Jorge Luis Flores, O. Novaro   +2 more
openalex   +1 more source

A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands

ChemMedChem, EarlyView.
A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova, Thomas M. Geiger, Lorenzo Cianni, Dominika E. Pieńkowska, Jan Gerhartz, Lina Read, Aleša Bricelj, Alexander Herrmann, Maurice Leon Nelles, Yuen Lam Dora Ng, Marcus D. Hartmann, Jan Krönke, Izidor Sosič, Radosław P. Nowak, Michael Gütschow, Christian Steinebach   +15 more
wiley   +1 more source

Eyelid Arteriovenous Malformation With Orbital Fistula: Literature Review and Case Report. [PDF]

Cureus
Ludovico I, Rodrigues Alves N, Neves T, Fragata I, Magriço A.   +4 more
europepmc   +1 more source

Searching for Novel Antiviral Agents as COVID19 Treatments: Guanidino Diaryl Thioureas

ChemMedChem, EarlyView.
Structure of the "hit‐compound" found and the proposed interaction with the active site of the TMPRSS2 protease, involving a reversible mechanism of action, are shown. The COVID‐19 pandemic highlighted the urgent need for effective antiviral treatments targeting SARS‐CoV‐2.
Marco Minneci, Barbara Farkaš, Adeyemi Rahman, Amy Kempf, Inga Nehlmeier, Stefan Pöhlmann, Isabel Rozas   +6 more
wiley   +1 more source

Aroma Profiling and Sensory Association of Six Raspberry Cultivars Using HS-SPME/GC-MS and OPLS-HDA. [PDF]

Foods
Ljujić J, Anđelković B, Sofrenić I, Simić K, Vujisić L, Batić N, Ivanović S, Gođevac D.   +7 more
europepmc   +1 more source

Multi-trait ridge regression BLUP with <i>de novo</i> GWAS improves genomic prediction for haploid induction ability of haploid inducers in maize. [PDF]

Front Plant Sci
Chen YR, Frei UK, Lübberstedt T.
europepmc   +1 more source