Results 81 to 90 of about 324,149 (330)

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Magical Realism in Isabel Allende's The House of the Spirits- A study

International journal of creative research thoughts
Magical realism is a literary genre that weaves elements of the extraordinary and supernatural into a realistic narrative, giving a sense of wonder and elevating the reader's experience. Latin American authors are known for their expertise in this genre,
P. Sujatha, Y. S. Sharada
semanticscholar   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Manifestations of magical realism in the novel"Al wali Attaher returnes to his pure shrine" by TaherWattar (Study of place, time and characters) [PDF]

دراسات في اللغة العربيّة وآدابها
Magical realism is a new approach to writing contemporary novels in which reality and fantasy are intertwined in such a way that all unreal and imaginary events in the context of the novel appear completely real and natural.
Zahra Haghayeghi, Ahmadreza Heidaryan Shahri, Zahra Makki   +2 more
doaj   +1 more source

Navigating Identity and Belonging Through Magical Realism: A Comparative Study of Cristina García and Ben Okri

International Journal For Multidisciplinary Research
This study explores the intersection of magical realism and transnational feminism in Cristina García’s Dreaming in Cuban and Ben Okri’s The Famished Road, examining how both authors employ magical realism to navigate the complex themes of identity ...
C. A, T. Akila
semanticscholar   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

The Magical Sublime: A New-old Lens On Magical Realism

, 2006
While magical realist critics often refer to magical realism\u27s generic heritage of primitive cultures and indigenous mythology, Franz Roh\u27s magischer realismus, and Surrealism, I will point to the sublime as a less recognized lineage, yet one which
Sasser, Kim Danielle
core   +1 more source

CLRe: A Synergistic Dual‐Engine Framework for One‐Step Retrosynthesis Prediction

Advanced Science, EarlyView.
CLRe uses a contrastive difficulty score to order pretrained seq2seq fine‐tuning for retrosynthesis. Reaction embeddings define the ranking score, and a cumulative easy‐to‐hard schedule expands from the easiest subset to the full training set while earlier examples remain active.
Tianhao Su, Xitao Wang, Musen Li, Guanhua Qin, Shunbo Hu, Tong‐Yi Zhang   +5 more
wiley   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

THE EXISTENCE OF MAGICAL REALISM IN COCO (2017) AND KNIGHT KRIS (2017) FILMS: A COMPARATIVE LITERARY STUDIES

Journal of Intensive Studies on Language, Literature, Art, and Culture
The film is one of the world's most famous contemporary literary works. Apart from having engaging visuals, films also contain messages. Film research has art elements that bridge society's culture and beliefs that reflect social reality, cultural values,
Cahyani Fajrin, H. Santoso, Poetri Mardiana Sasti, Yufita Ng   +3 more
semanticscholar   +1 more source