Results 81 to 90 of about 1,471,670 (347)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Effects of nanofeatures induced by severe shot peening (SSP) on mechanical, corrosion and cytocompatibility properties of magnesium alloy AZ31. [PDF]

Acta Biomaterialia, 2017
The application of biodegradable magnesium-based materials in the biomedical field is highly restricted by their low fatigue strength and high corrosion rate in biological environments.
S. Bagherifard, Daniel J. Hickey, S. Fintová, F. Pastorek, I. Fernández-Pariente, M. Bandini, T. Webster, M. Guagliano   +7 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The misalignment between degradation rate and mechanical integrity of Mg-Zn-Y-Nd alloy during the degradation evaluation in modified Hanks' solutions

Journal of Magnesium and Alloys
The degradation behavior of biodegradable Mg alloys has become a research hotspot in the fields about biodegradable metallic materials. While the most of the related publications mainly focused on the degradation rate of Mg-based materials, but rare to ...
Di Mei, Qingyuan Zhang, Yaqian Li, Mengyao Liu, Wenkai Li, Pingli Jiang, Ruiqing Hou, Shijie Zhu, Liguo Wang, Shaokang Guan   +9 more
doaj   +1 more source

In Vivo Corrosion of Two Novel Magnesium Alloys ZEK100 and AX30 and Their Mechanical Suitability as Biodegradable Implants [PDF]

, 2011
In magnesium alloys, the components used modify the alloy properties. For magnesium implants in contact with bone, rare earths alloys are commonly examined.
Angrisani, Nina, Bormann, Dirk, Huehnerschulte, Tim Andreas, Meyer-Lindenberg, Andrea, Rittershaus, Dina, Windhagen, Henning   +5 more
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Biocompatibility, Degradation Behavior, and Mechanical Properties of Magnesium Alloy Plates In Vivo

Applied Bionics and Biomechanics, 2023
The magnesium alloy was made into orthopedic steel plates to repair tibial fractures of New Zealand white rabbits and to explore the biocompatibility, degradation behavior, and mechanical properties of the magnesium alloy plates in repairing fractures in
Yongping Wang, Qingqing Qin, Xiaorong Liu, Qiangqiang Li, Huaibin Zhang, Dubin Yang, Yao Jiang   +6 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Adherent protective coatings plated on magnesium-lithium alloy [PDF]

, 1965
Zinc is plated on a magnesium-lithium alloy by using a modification of the standard zinc-plate immersion bath. Further protection is given the alloy by applying a light plating of copper on the zinc plating. Other metals are plated on the copper by using

core   +1 more source

Hydrogen production by methanol steam reforming on NiSn/MgO-Al 2O3 catalysts: The role of MgO addition [PDF]

, 2011
The effect of the magnesia loading on the surface structure and catalytic properties of NiSn/MgO-Al2O3 catalysts for hydrogen production by methanol steam reforming has been investigated. The catalysts have been obtained by impregnation of γ-Al2O3 by the
Bobadilla Baladrón, Luis Francisco, Centeno Gallego, Miguel Ángel, Domínguez Leal, María Isabel, Ivanova, Svetlana, Odriozola Gordón, José Antonio, Penkova, Anna Dimitrova, Roger, Anne-Cécile, Romero Sarria, Francisca   +7 more
core   +1 more source