Results 71 to 80 of about 56,156 (291)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Replenishment of intracellular magnesium deficiency in cardiac arrhythmias: focus on the physicochemical properties of complex compounds

Рациональная фармакотерапия в кардиологии
Aim. To identify the most promising drug composition for replenishing intracellular magnesium deficiency by eveluating the physicochemical properties of magnesium complex compounds and conducting experiments on isolated rat atrial cardiomyocytes ...
Ya. G. Bozhko, N. A. Belokonova, O. M. Medvedeva, K. A. Butova, M. V. Arkhipov   +4 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Red blood cell magnesium content in individuals aged 65 years and older with asthenia and sarcopenia

Российский журнал гериатрической медицины
ACTUALITY. In clinical practice, magnesium deficiency in the body is detected in cardiovascular, bronchopulmonary, rheumatological diseases and neurodegenerative diseases.
N. V. Voronina, Yu. V. Yankovskaya, O. G. Garbuzova   +2 more
doaj   +1 more source

Chronic magnesium deficiency [PDF]

Proceedings of the Nutrition Society, 1962
P, FOURMAN, D B, MORGAN
openaire   +2 more sources

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Female magnesium deficiency and its management: review of current knowledge

Акушерство, гинекология и репродукция
Magnesium is an important cofactor for metabolic reactions involving more than 300 enzymes, regulating a series of fundamental processes, such as myocardial contraction and blood pressure control, glucose regulation, participation in neuromuscular ...
A. D. Makatsariya, V. O. Bitsadze, A. G. Solopova, O. A. Gromova, D. I. Korabelnikov, D. V. Blinov, J. Kh. Khizroeva, N. A. Makatsariya, M. V. Tretyakova, S. A. Akavova, D. M. Ampilogova   +10 more
doaj   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Magnesium deficiency and its relationship with obstetrical pathology

Медицинский совет, 2013
Over the recent decades researchers have been concerned about magnesium deficiency in the population. There is an increase in the frequency of detection of magnesium deficiency in the studied population, and there is evidence of deficiency relationship ...
I. Yu. Fofanova
doaj   +1 more source