Results 81 to 90 of about 22,586 (294)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

The chemical compositions of the 2 new HgMn stars HD 30085 and HD 30963. Comparison to $χ$ Lupi A, $ν$ Cap and HD 174567 [PDF]

open access: yes, 2019
We report on a detailed abundance study of the fairly bright slow rotators HD 30085 (A0 IV), HD 30963 (B9 III) and HD 174567 (A0 V), hitherto reported as normal stars and the sharp-lined chi Lupi A (B9 IV HgMn). In the spectra of HD 30085, HD 30963, the Hg II line at 3984 A line is conspicuous and numerous lines of silicon, manganese, chromium ...
arxiv   +1 more source

Microglial reprogramming: a potential new frontier in enhancing immunotherapy for melanoma brain metastasis

open access: yesMolecular Oncology, EarlyView.
Microglia act as tumor suppressors during brain metastasis colonization but shift to a tumor‐promoting role after melanoma brain metastases form. NF‐κB/RelA signaling emerges as a key driver of this phenotypic shift. Targeting this pathway reprograms microglia into a pro‐inflammatory state, enhancing antitumor immunity and immune checkpoint inhibitor ...
Noam Savion‐Gaiger   +2 more
wiley   +1 more source

A fully labelled image dataset of banana leaves deficient in nutrients

open access: yesData in Brief, 2023
Agriculture is the art and science of cultivating the soil, growing crops and raising livestock. Enhancing crop yield becomes essential to improve economy in agriculture sector. Crops need 16 essential nutrients in balanced factor for their proper growth.
Sunitha P   +3 more
doaj  

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

Metal abundances in PG1159 stars from Chandra and FUSE spectroscopy [PDF]

open access: yesarXiv, 2002
We investigate FUSE spectra of three PG1159 stars and do not find any evidence for iron lines. From a comparison with NLTE models we conclude a deficiency of 1-1.5 dex. We speculate that iron was transformed into heavier elements. A soft X-ray Chandra spectrum of the unique H- and He-deficient star H1504+65 is analyzed.
arxiv  

Faint Population III supernovae as the origin of the most iron-poor stars [PDF]

open access: yes, 2014
The most iron-deficient stars in the Milky Way provide important observational constraints on the nature of astrophysical objects that have enriched the primordial gas with heavy elements from which these stars were formed. Among them, the recently discovered iron-deficient star SMSS J031300.36-670839.3 shows a remarkable chemical composition with non ...
arxiv   +1 more source

Purification and characterization of a thermophilic NAD+‐dependent lactate dehydrogenase from Moorella thermoacetica

open access: yesFEBS Open Bio, EarlyView.
The thermophilic acetogenic model organism Moorella thermoacetica can utilize lactate as substrate. The formation of lactate by reduction of pyruvate is energetically favorable, but the reverse reaction, the oxidation of lactate to pyruvate with NAD+ as electron acceptor is challenging.
Florian P. Rosenbaum, Volker Müller
wiley   +1 more source

Effect of added magnesium, potassium, lime and nitrogen on oats: I. Yields

open access: yesAgricultural and Food Science, 1977
With peat as the growth base the effect of the various combinations of three amounts of magnesium, of three of potassium, of two of lime and two of nitrogen on the grain and the straw crop yields, grown in pots, was investigated. During three seasons the
Raili Jokinen
doaj  

FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production

open access: yesFEBS Open Bio, EarlyView.
FAM136A depletion upregulated ROS production, reduced mitochondrial membrane potential (ΔΨ) and ATP production, and upregulated expression of PCK1, PCK2, HMGCS1, and HMGCS2. The expression of both TOMM22 and TOMM20 was also upregulated. FAM136A depletion reduced HCCS that produce holocytochrome c by combining heme to apocytochrome c, and reduced the ...
Yushi Otsuka, Masato Yano
wiley   +1 more source

Home - About - Disclaimer - Privacy