Results 81 to 90 of about 47,563 (259)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

A fully labelled image dataset of banana leaves deficient in nutrients

Data in Brief, 2023
Agriculture is the art and science of cultivating the soil, growing crops and raising livestock. Enhancing crop yield becomes essential to improve economy in agriculture sector. Crops need 16 essential nutrients in balanced factor for their proper growth.
Sunitha P, Uma B, Channakeshava S, Suresh Babu C S   +3 more
doaj  

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Managing Alaska Soils [PDF]

, 2010
This publication is for the gardener who wants to gain a more thorough understanding of soil basics, including soil components, texture, structure, water permeability and chemistry.
Jahns, Thomas R.
core  

Genome wide association mapping of grain arsenic, copper, molybdenum and zinc in rice (Oryza sativa L.) grown at four international field sites [PDF]

, 2014
Peer reviewedPublisher ...
A Gasber, A Korte, Adam H. Price, AE Anastasio, AL Garcia-Oliveira, AL Price, Alex Douglas, AN Famoso, Andrew A. Meharg, BM Waters, Brett Lahner, C Toomajian, CW Tung, D Mondal, David E. Salt, EE Adomako, Elena Yakubova, Fang-Jie Zhao, G Sun, Gareth J. Norton, GC Eizenga, Georgia C. Eizenga, GJ Norton, GJ Norton, GJ Norton, GJ Norton, GJ Norton, Guilan Duan, H Tomatsu, I Baxter, J Yu, J Zhang, Jauhar Ali, JCR Stangoulis, JF Ma, K Cui, K Lu, K Ohno, K Zhao, K Zhao, KA Mather, KL Fitzpatrick, Lee Tarpley, M Tejada-Jimenez, M Yuan, M Yuan, M. Rafiqul Islam, Mary Lou Guerinot, ML Kile, MW Horton, PJ White, PN Williams, R Graham, R Tuli, RR Mendel, S Atwell, S Lee, S Lee, SA Ramesh, Shannon R. M. Pinson, Shofiqul Islam, SL Jiang, SL Jiang, SP Kiani, Steve P. McGrath, T Agusa, TR Pillai, W Maret, X Huang, X Huang, X Yang, X Zhang, XY Xu, Y Ishimaru, Y Li, Y Lu, Y Zeng, Yongguan Zhu, YZ Xing, ZU Ahmed   +79 more
core   +7 more sources

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Effect of added magnesium, potassium, lime and nitrogen on oats: I. Yields

Agricultural and Food Science, 1977
With peat as the growth base the effect of the various combinations of three amounts of magnesium, of three of potassium, of two of lime and two of nitrogen on the grain and the straw crop yields, grown in pots, was investigated. During three seasons the
Raili Jokinen
doaj  

Nutritional Disorders of Grain Sorghum [PDF]

Crop Production/Industries,
Asher, Colin J., Clark, R.B., Edwards, D.G., Grundon, Noel J., Takkar, P.N.   +4 more
core   +1 more source

Effect of Processing Methods on Nutritive and Antinutritive Properties of Seeds of Brachystegia eurycoma and Detarium microcarpum from Nigeria [PDF]

, 2009
Proximate analysis of the seeds of Brachystegia eurycoma and Detrarium microcarpum were carried out on both the dehulled and undehulled samples of the flour.
Iweala, E. E. J., Kanu, Ijeoma, Onwuchekwa, C. C., Uhuegbu, F. O.   +3 more
core   +1 more source