Results 61 to 70 of about 9,287 (256)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Fabrication of Magnesium–NiTi_p Composites via Friction Stir Processing: Effect of Tool Profile

Metals, 2020
In this study, a solid-state fabrication route via friction stir processing (FSP) was used to fabricate Nitinol particulate (NiTip)-reinforced magnesium-based composites to avoid the diffusion reaction and the formation of brittle interfacial compounds ...
N. Gangil, H. Nagar, S.M.A.K. Mohammed, D. Singh, A.N. Siddiquee, S. Maheshwari, D.L. Chen   +6 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Synthesis and molecular dynamics investigation of Mg/SiCP composites with high thermal conductivity and low expansion

Journal of Magnesium and Alloys
The critical challenge of chip thermal dissipation fundamentally constrains both power consumption and operational longevity, underscoring the imperative demand for advanced packaging materials exhibiting superior thermal conductivity coupled with ...
Lu Chen, Mingzi Wang, Wenbo Guo, Jianyu Li, Shulin Lü, Wei Guo, Shusen Wu   +6 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Laser powder bed fusion of Mg-6Gd-3Y-0.2Zr alloy: Excellent printability, heterogeneous microstructure and dedicated direct aging heat treatment

Journal of Magnesium and Alloys
As a universal casting Mg-RE alloy, Mg-6Gd-3Y-Zr (GW63K, wt.%) alloy exhibits superior strength-ductility synergy and holds significant potential for engineering applications.
Qingchen Deng, Jing Luo, Ziyi Liu, Qianye Wu, Dazhi Liu, Lianmei Wu, Fei Li, Manman Yi, Penghuai Fu, Yujuan Wu, Liming Peng, Wenjiang Ding   +11 more
doaj   +1 more source

Multiscale modeling of interfacial mechanical behaviours of SiC/Mg nanocomposites

Materials & Design, 2019
The aim of this investigation is to predict the interface separation behavior of silicon carbide (SiC) reinforced magnesium (Mg) matrix composites via multiscale simulations.
Xia Zhou, Wenming Bu, Shangyu Song, Frederic Sansoz, Xiaorun Huang   +4 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Microstructural and mechanical behavior analysis of magnesium matrix composites with varying Al2O3 content

Scientific Reports
The Magnesium metal matrix composites demonstrate extremely high potentials of using light materials that are strong in the various industries. As the modern process, the fabrication and synthesis of Magnesium matrix composites which have fortified Al2O3
K. Muthusamy, A. Muthiah
doaj   +1 more source