Results 61 to 70 of about 9,234 (260)

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Synthesis and molecular dynamics investigation of Mg/SiCP composites with high thermal conductivity and low expansion

Journal of Magnesium and Alloys
The critical challenge of chip thermal dissipation fundamentally constrains both power consumption and operational longevity, underscoring the imperative demand for advanced packaging materials exhibiting superior thermal conductivity coupled with ...
Lu Chen, Mingzi Wang, Wenbo Guo, Jianyu Li, Shulin Lü, Wei Guo, Shusen Wu   +6 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Laser powder bed fusion of Mg-6Gd-3Y-0.2Zr alloy: Excellent printability, heterogeneous microstructure and dedicated direct aging heat treatment

Journal of Magnesium and Alloys
As a universal casting Mg-RE alloy, Mg-6Gd-3Y-Zr (GW63K, wt.%) alloy exhibits superior strength-ductility synergy and holds significant potential for engineering applications.
Qingchen Deng, Jing Luo, Ziyi Liu, Qianye Wu, Dazhi Liu, Lianmei Wu, Fei Li, Manman Yi, Penghuai Fu, Yujuan Wu, Liming Peng, Wenjiang Ding   +11 more
doaj   +1 more source

Multiscale modeling of interfacial mechanical behaviours of SiC/Mg nanocomposites

Materials & Design, 2019
The aim of this investigation is to predict the interface separation behavior of silicon carbide (SiC) reinforced magnesium (Mg) matrix composites via multiscale simulations.
Xia Zhou, Wenming Bu, Shangyu Song, Frederic Sansoz, Xiaorun Huang   +4 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Strengthening/weakening effect of graphene orientation angle on mechanical properties of AZ91 magnesium matrix composites

Journal of Magnesium and Alloys
Graphene, as the reinforcing phase of magnesium matrix composites, can effectively improve the material strength, elastic modulus, and other properties. However, the random distribution of graphene in the matrix (i.e., random orientation angle) leads to ...
Dunwei Peng, Zhuo Song, Yunpeng Zhang, Xiaopan Wang, Hua Hou, Yuhong Zhao   +5 more
doaj   +1 more source