Safety of Magnesium Orotate Dihydrate as a Novel Food Pursuant to Regulation (EU) 2015/2283 and Bioavailability of Magnesium From This Source in the Context of Directive 2002/46/EC [PDF]
EFSA JournalFollowing a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of magnesium orotate dihydrate as a novel food (NF) pursuant to Regulation (EU) 2015/2283 ...
Alexandre Maciuk +2 more
exaly +5 more sources
Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial [PDF]
Scientific ReportsFollowing on from our pilot studies, this study aimed to test the efficacy of a combination of probiotics (Lactobacillus acidophilus, Bifidobacterium bifidum, Streptococcus thermophilus), magnesium orotate and coenzyme 10 for the treatment of major ...
Esben Strodl +5 more
doaj +8 more sources
MOLECULAR MECHANISMS OF ACTION OF MAGNESIUM OROTATE ON CARDIOVASCULAR SYSTEM [PDF]
Рациональная фармакотерапия в кардиологии, 2016 Orotic acid is one of the intermediates in the pyrimidine biosynthesis. Mechanisms of physiological effects of orotic acid are poorly known. Analysis of data about these mechanisms is presented.
I. Yu. Torshin, O. A. Gromova
doaj +4 more sources
RUDN Journal of Medicine, 2021 Relevance. The topicality of the work is determined by the wide spread of hypomagnesemia among the people, which makes it necessary to correct it. The aim of the work is to elucidate the cell-mediated response of the thymus mastocytic link to magnesium ...
Natalya Chuchkova +2 more
exaly +9 more sources
Investigation of the effects of magnesium orotate in a model of primary generalized seizures
Неврология, нейропсихиатрия, психосоматика, 2017 Objective: to investigate the anticonvulsant and neuroprotective effects of magnesium orotate in a rat thiosemicarbazide model of seizures in rats.Material and methods.
A. G. Kalacheva +6 more
doaj +3 more sources
Change in Content of Glycoproteins on the Surface of Endothelial Cell Culture EA.Hy 926 and Intima of Internal Carotid Arteries Under the Influence of Magnesium Orotate [PDF]
Rational Pharmacotherapy in Cardiology, 2017 Aim. To study changes in the glycoproteins content in the glycocalyx of endothelial cells under the influence of magnesium orotate.Material and methods.
Natalya V Shevlyagina +1 more
exaly +4 more sources
Magnesium Orotate and the Microbiome–Gut–Brain Axis Modulation: New Approaches in Psychological Comorbidities of Gastrointestinal Functional Disorders [PDF]
Nutrients, 2022 Magnesium orotate has been cited in the medical literature for the past three years as a possible adjuvant in some pediatric and adult gastroenterological disorders associated with dysbiosis.
Smaranda Diaconescu +2 more
exaly +3 more sources
Magnesium Orotate Influence on Thoracic Aorta in Laboratory Rabbits Receiving Levofloxacin
Safety and Risk of PharmacotherapyINTRODUCTION. Fluoroquinolones are antibacterial agents associated with adverse drug reactions (ARDs), including aortic lesions; this ARD risk limits the use of fluoroquinolones.
Larisa Polushina +2 more
exaly +4 more sources
Effects of Magnesium Orotate, Benfotiamine and a Combination of Vitamins on Mitochondrial and Cholinergic Function in the TgF344-AD Rat Model of Alzheimer’s Disease [PDF]
Pharmaceuticals, 2021 Glucose hypometabolism, mitochondrial dysfunction, and cholinergic deficits have been reported in early stages of Alzheimer’s disease (AD). Here, we examine these parameters in TgF344-AD rats, an Alzheimer model that carries amyloid precursor protein and
Christian Viel +5 more
doaj +2 more sources
Archives of Biochemistry and Biophysics, 1993 Orotate phosphoribosyltranferase (OPRTase) catalyzes the formation of orotidine 5'-monophosphate from the nitrogenous base orotate and alpha-D-5-phosphoribosyl-1-pyrophosphate (PRPP). While it is known that Mg2+ is necessary for catalysis, the mechanism of activation of the phosphoribosyl transfer by Mg2+ remains unclear.
C Grubmeyer
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